Fig. 6. Post-stress treatment with Lpc-EV improved stress-induced depressive-like behavior in CRST mice. (A) Experimental design. CRST mice were treated with imipramine (IMI) or Lpc-EV for 14 days. Behavior tests were performed on post-stress days 15~16 (p15~p16). Control mice injected with saline (CON+veh), mice treated with CRST (CRST+veh), CRST treated with IMI (CRST+IMI), and CRST treated with Lpc-EV (CRST+Lpc-EV). Lpc-EV, 2 μg/100 ul/mouse/day (i.p.). n=10~12 animals. (B, C) Social interaction time of the indicated groups spent in the target vs. non-target fields in the U-shaped two-choice sociability test. A diagram of the U-shaped two-choice field (right panel). (D, E) Immobility time in the TST (D) and FST (E) for the indicated groups. Data are presented as the mean±SEM. *p<0.05; **p<0.01 (one-way ANOVA followed by Newman-Keuls post hoc test).
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