Fig. 4. The Aged ANKS1A brains show an increased mesenchymal marker expression. (A) The image shows an increase in fibronectin positive signals in the CCM-like vessel lesions (scale bar, 10 μm). (B) The data in the panel A was quantified and presented as means presented as means±SD (N=3 per group, n=8). (C) The image shows several Sca-1 positive signals can be seen in the CCM-like vessels lesions, indicating a proliferation potential of the cells (scale bar, 10 μm). (D) The data in the panel C was quantified and presented as means presented as means±SD (N=3 per group, n=8). (E) The images show an increase in fibronectin positive signals in primary brain endothelial cells derived from ANKS1A KO mice (scale bar, 10 μm). (F) The data were quantified and presented as means±SD (N=3 per group, n=10 microscopic fields for each group). (G) The images show an enhanced Ki67 positive staining in primary brain endothelial cells derived from ANKS1A KO mice (scale bar, 10 μm). (H) The data were quantified and presented as means±SD (N=3 per group, ANKS1A+/+ n=13, ANKS1A-/- n=10 microscopic fields for each group).
© Exp Neurobiol
