The diagnostic processes for seronegative AIE
Diagnostic criteria | Description |
---|---|
Clinical presentation | Rapid onset of working memory deficits, altered mental status, or psychiatric symptoms. |
MRI | Potential abnormalities, especially in the medial temporal lobes. |
CSF analysis | Elevated white cell count (pleocytosis) or increased protein concentration. |
EEG | Abnormalities such as epileptic or slow-wave activity. |
Absence of alternate causes | Ruling out other potential causes like infections, metabolic disturbances, or tumors. |
Response to immune therapy | Supportive of diagnosis if there's a response to treatments like steroids, IVIG, or plasmapheresis. |
Autoantibody status | Absence of specific neural autoantibodies in serum. |
IVIG, intravascular immunoglobulin therapy.