Lee SH, Shim J, Kaang BK (2013) The role of cell adhesion molecules (CAMs) in defining synapse-specific function and plasticity. Anim Cells Syst 17:1-6.
Conant K, Allen M, Lim ST (2015) Activity dependent CAM cleavage and neurotransmission. Front Cell Neurosci 9:305.
Takeichi M (1995) Morphogenetic roles of classic cadherins. Curr Opin Cell Biol 7:619-627.
Samanta D, Almo SC (2015) Nectin family of cell-adhesion molecules: structural and molecular aspects of function and specificity. Cell Mol Life Sci 72:645-658.
Washbourne P, Dityatev A, Scheiffele P, Biederer T, Weiner JA, Christopherson KS, El-Husseini A (2004) Cell adhesion molecules in synapse formation. J Neurosci 24:9244-9249.
Dalva MB, McClelland AC, Kayser MS (2007) Cell adhesion molecules: signalling functions at the synapse. Nat Rev Neurosci 8:206-220.
Sytnyk V, Leshchyns'ka I, Schachner M (2017) Neural cell adhesion molecules of the immunoglobulin superfamily regulate synapse formation, maintenance, and function. Trends Neurosci 40:295-308.
Zinn K, Özkan E (2017) Neural immunoglobulin superfamily interaction networks. Curr Opin Neurobiol 45:99-105.
Tan RPA, Leshchyns'ka I, Sytnyk V (2017) Glycosylphosphatidylinositolanchored immunoglobulin superfamily cell adhesion molecules and their role in neuronal development and synapse regulation. Front Mol Neurosci 10:378.
Sanz R, Ferraro GB, Fournier AE (2015) IgLON cell adhesion molecules are shed from the cell surface of cortical neurons to promote neuronal growth. J Biol Chem 290:4330-4342.
Gil OD, Zanazzi G, Struyk AF, Salzer JL (1998) Neurotrimin mediates bifunctional effects on neurite outgrowth via homophilic and heterophilic interactions. J Neurosci 18:9312-9325.
Lodge AP, Howard MR, McNamee CJ, Moss DJ (2000) Colocalisation, heterophilic interactions and regulated expression of IgLON family proteins in the chick nervous system. Brain Res Mol Brain Res 82:84-94.
Chen S, Gil O, Ren YQ, Zanazzi G, Salzer JL, Hillman DE (2001) Neurotrimin expression during cerebellar development suggests roles in axon fasciculation and synaptogenesis. J Neurocytol 30:927-937.
Pimenta AF, Zhukareva V, Barbe MF, Reinoso BS, Grimley C, Henzel W, Fischer I, Levitt P (1995) The limbic systemassociated membrane protein is an Ig superfamily member that mediates selective neuronal growth and axon targeting. Neuron 15:287-297.
Struyk AF, Canoll PD, Wolfgang MJ, Rosen CL, D'Eustachio P, Salzer JL (1995) Cloning of neurotrimin defines a new subfamily of differentially expressed neural cell adhesion molecules. J Neurosci 15(3 Pt 2):2141-2156.
Wilson DJ, Kim DS, Clarke GA, Marshall-Clarke S, Moss DJ (1996) A family of glycoproteins (GP55), which inhibit neurite outgrowth, are members of the Ig superfamily and are related to OBCAM, neurotrimin, LAMP and CEPU-1. J Cell Sci 109 (Pt 13):3129-3138.
Williams AF, Barclay AN (1988) The immunoglobulin superfamily--domains for cell surface recognition. Annu Rev Immunol 6:381-405.
Chothia C, Jones EY (1997) The molecular structure of cell adhesion molecules. Annu Rev Biochem 66:823-862.
Funatsu N, Miyata S, Kumanogoh H, Shigeta M, Hamada K, Endo Y, Sokawa Y, Maekawa S (1999) Characterization of a novel rat brain glycosylphosphatidylinositol-anchored protein (Kilon), a member of the IgLON cell adhesion molecule family. J Biol Chem 274:8224-8230.
Miyata S, Funatsu N, Matsunaga W, Kiyohara T, Sokawa Y, Maekawa S (2000) Expression of the IgLON cell adhesion molecules Kilon and OBCAM in hypothalamic magnocellular neurons. J Comp Neurol 424:74-85.
Schäfer M, Bräuer AU, Savaskan NE, Rathjen FG, Brümmendorf T (2005) Neurotractin/kilon promotes neurite outgrowth and is expressed on reactive astrocytes after entorhinal cortex lesion. Mol Cell Neurosci 29:580-590.
Miyata S, Matsumoto N, Taguchi K, Akagi A, Iino T, Funatsu N, Maekawa S (2003) Biochemical and ultrastructural analyses of IgLON cell adhesion molecules, Kilon and OBCAM in the rat brain. Neuroscience 117:645-658.
Singh K, Jayaram M, Kaare M, Leidmaa E, Jagomäe T, Heinla I, Hickey MA, Kaasik A, Schäfer MK, Innos J, Lilleväli K, Philips MA, Vasar E (2019) Neural cell adhesion molecule Negr1 deficiency in mouse results in structural brain endophenotypes and behavioral deviations related to psychiatric disorders. Sci Rep 9:5457.
Pischedda F, Piccoli G (2016) The IgLON family member Negr1 promotes neuronal arborization acting as soluble factor via FGFR2. Front Mol Neurosci 8:89.
Hashimoto T, Yamada M, Maekawa S, Nakashima T, Miyata S (2008) IgLON cell adhesion molecule Kilon is a crucial modulator for synapse number in hippocampal neurons. Brain Res 1224:1-11.
Pischedda F, Szczurkowska J, Cirnaru MD, Giesert F, Vezzoli E, Ueffing M, Sala C, Francolini M, Hauck SM, Cancedda L, Piccoli G (2014) A cell surface biotinylation assay to reveal membrane-associated neuronal cues: Negr1 regulates dendritic arborization. Mol Cell Proteomics 13:733-748.
Szczurkowska J, Pischedda F, Pinto B, Managò F, Haas CA, Summa M, Bertorelli R, Papaleo F, Schäfer MK, Piccoli G, Cancedda L (2018) NEGR1 and FGFR2 cooperatively regulate cortical development and core behaviours related to autism disorders in mice. Brain 141:2772-2794.
Willer CJ1, Speliotes EK, Loos RJ, Li S, Lindgren CM, Heid IM, Berndt SI, Elliott AL, Jackson AU, Lamina C, Lettre G, Lim N, Lyon HN, McCarroll SA, Papadakis K, Qi L, Randall JC, Roccasecca RM, Sanna S, Scheet P, Weedon MN, Wheeler E, Zhao JH, Jacobs LC, Prokopenko I, Soranzo N, Tanaka T, Timpson NJ, Almgren P, Bennett A, Bergman RN, Bingham SA, Bonnycastle LL, Brown M, Burtt NP, Chines P, Coin L, Collins FS, Connell JM, Cooper C, Smith GD, Dennison EM, Deodhar P, Elliott P, Erdos MR, Estrada K, Evans DM, Gianniny L, Gieger C, Gillson CJ, Guiducci C, Hackett R, Hadley D, Hall AS, Havulinna AS, Hebebrand J, Hofman A, Isomaa B, Jacobs KB, Johnson T, Jousilahti P, Jovanovic Z, Khaw KT, Kraft P, Kuokkanen M, Kuusisto J, Laitinen J, Lakatta EG, Luan J, Luben RN, Mangino M, McArdle WL, Meitinger T, Mulas A, Munroe PB, Narisu N, Ness AR, Northstone K, O'Rahilly S, Purmann C, Rees MG, Ridderstråle M, Ring SM, Rivadeneira F, Ruokonen A, Sandhu MS, Saramies J, Scott LJ, Scuteri A, Silander K, Sims MA, Song K, Stephens J, Stevens S, Stringham HM, Tung YC, Valle TT, Van Duijn CM, Vimaleswaran KS, Vollenweider P, Waeber G, Wallace C, Watanabe RM, Waterworth DM, Watkins N; Wellcome Trust Case Control Consortium, Witteman JC, Zeggini E, Zhai G, Zillikens MC, Altshuler D, Caulfield MJ, Chanock SJ, Farooqi IS, Ferrucci L, Guralnik JM, Hattersley AT, Hu FB, Jarvelin MR, Laakso M, Mooser V, Ong KK, Ouwehand WH, Salomaa V, Samani NJ, Spector TD, Tuomi T, Tuomilehto J, Uda M, Uitterlinden AG, Wareham NJ, Deloukas P, Frayling TM, Groop LC, Hayes RB, Hunter DJ, Mohlke KL, Peltonen L, Schlessinger D, Strachan DP, Wichmann HE, McCarthy MI, Boehnke M, Barroso I, Abecasis GR, Hirschhorn JN; Genetic Investigation of ANthropometric Traits Consortium (2009) Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet 41:25-34.
Zhao J, Bradfield JP, Li M, Wang K, Zhang H, Kim CE, Annaiah K, Glessner JT, Thomas K, Garris M, Frackelton EC, Otieno FG, Shaner JL, Smith RM, Chiavacci RM, Berkowitz RI, Hakonarson H, Grant SF (2009) The role of obesity-associated loci identified in genome-wide association studies in the determination of pediatric BMI. Obesity (Silver Spring) 17:2254-2257.
Jarick I, Vogel CI, Scherag S, Schäfer H, Hebebrand J, Hinney A, Scherag A (2011) Novel common copy number variation for early onset extreme obesity on chromosome 11q11 identified by a genome-wide analysis. Hum Mol Genet 20:840-852.
Bernhard F, Landgraf K, Klöting N, Berthold A, Büttner P, Friebe D, Kiess W, Kovacs P, Blüher M, Körner A (2013) Functional relevance of genes implicated by obesity genome-wide association study signals for human adipocyte biology. Diabetologia 56:311-322.
Mägi R, Manning S, Yousseif A, Pucci A, Santini F, Karra E, Querci G, Pelosini C, McCarthy MI, Lindgren CM, Batterham RL (2013) Contribution of 32 GWAS-identified common variants to severe obesity in European adults referred for bariatric surgery. PLoS One 8:e70735.
Poveda A, Ibáñez ME, Rebato E (2014) Common variants in BDNF, FAIM2, FTO, MC4R, NEGR1, and SH2B1 show association with obesity-related variables in Spanish Roma population. Am J Hum Biol 26:660-669.
Martínez-García F, Mansego ML, Rojo-Martínez G, De MarcoSolar G, Morcillo S, Soriguer F, Redón J, Pineda Alonso M, Martín-Escudero JC, Cooper RS, Chaves FJ (2013) Impact of obesity-related genes in Spanish population. BMC Genet 14:111.
Ntalla I, Panoutsopoulou K, Vlachou P, Southam L, William Rayner N, Zeggini E, Dedoussis GV (2013) Replication of established common genetic variants for adult BMI and childhood obesity in Greek adolescents: the TEENAGE study. Ann Hum Genet 77:268-274.
Elks CE, Loos RJ, Hardy R, Wills AK, Wong A, Wareham NJ, Kuh D, Ong KK (2012) Adult obesity susceptibility variants are associated with greater childhood weight gain and a faster tempo of growth: the 1946 British Birth Cohort Study. Am J Clin Nutr 95:1150-1156.
Renström F, Payne F, Nordström A, Brito EC, Rolandsson O, Hallmans G, Barroso I, Nordström P, Franks PW; GIANT Consortium (2009) Replication and extension of genomewide association study results for obesity in 4923 adults from Northern Sweden. Hum Mol Genet 18:1489-1496.
Hotta K, Kitamoto T, Kitamoto A, Mizusawa S, Matsuo T, Nakata Y, Kamohara S, Miyatake N, Kotani K, Komatsu R, Itoh N, Mineo I, Wada J, Yoneda M, Nakajima A, Funahashi T, Miyazaki S, Tokunaga K, Masuzaki H, Ueno T, Hamaguchi K, Tanaka K, Yamada K, Hanafusa T, Oikawa S, Yoshimatsu H, Sakata T, Matsuzawa Y, Nakao K, Sekine A (2011) Association of variations in the FTO, SCG3 and MTMR9 genes with metabolic syndrome in a Japanese population. J Hum Genet 56:647-651.
Cheung CY, Tso AW, Cheung BM, Xu A, Ong KL, Fong CH, Wat NM, Janus ED, Sham PC, Lam KS (2010) Obesity susceptibility genetic variants identified from recent genome-wide association studies: implications in a Chinese population. J Clin Endocrinol Metab 95:1395-1403.
Hotta K, Nakamura M, Nakamura T, Matsuo T, Nakata Y, Kamohara S, Miyatake N, Kotani K, Komatsu R, Itoh N, Mineo I, Wada J, Masuzaki H, Yoneda M, Nakajima A, Funahashi T, Miyazaki S, Tokunaga K, Kawamoto M, Ueno T, Hamaguchi K, Tanaka K, Yamada K, Hanafusa T, Oikawa S, Yoshimatsu H, Nakao K, Sakata T, Matsuzawa Y, Kamatani N, Nakamura Y (2009) Association between obesity and polymorphisms in SEC16B, TMEM18, GNPDA2, BDNF, FAIM2 and MC4R in a Japanese population. J Hum Genet 54:727-731.
Liu S, Wilson JG, Jiang F, Griswold M, Correa A, Mei H (2016) Multi-variant study of obesity risk genes in African Americans:the Jackson Heart Study. Gene 593:315-321.
Hester JM, Wing MR, Li J, Palmer ND, Xu J, Hicks PJ, Roh BH, Norris JM, Wagenknecht LE, Langefeld CD, Freedman BI, Bowden DW, Ng MC (2012) Implication of Europeanderived adiposity loci in African Americans. Int J Obes (Lond) 36:465-473.
Joo Y, Kim H, Lee S, Lee S (2019) Neuronal growth regulator 1-deficient mice show increased adiposity and decreased muscle mass. Int J Obes (Lond) 43:1769-1782.
Hinney A, Wolters B, Pütter C, Grallert H, Illig T, Hebebrand J, Reinehr T (2013) No impact of obesity susceptibility loci on weight regain after a lifestyle intervention in overweight children. J Pediatr Endocrinol Metab 26:1209-1213.
Ng MC, Tam CH, So WY, Ho JS, Chan AW, Lee HM, Wang Y, Lam VK, Chan JC, Ma RC (2010) Implication of genetic variants near NEGR1, SEC16B, TMEM18, ETV5/DGKG, GNPDA2, LIN7C/BDNF, MTCH2, BCDIN3D/FAIM2, SH2B1, FTO, MC4R, and KCTD15 with obesity and type 2 diabetes in 7705 Chinese. J Clin Endocrinol Metab 95:2418-2425.
Wang J, Mei H, Chen W, Jiang Y, Sun W, Li F, Fu Q, Jiang F (2012) Study of eight GWAS-identified common variants for association with obesity-related indices in Chinese children at puberty. Int J Obes (Lond) 36:542-547.
Lee AW, Hengstler H, Schwald K, Berriel-Diaz M, Loreth D, Kirsch M, Kretz O, Haas CA, de Angelis MH, Herzig S, Brümmendorf T, Klingenspor M, Rathjen FG, Rozman J, Nicholson G, Cox RD, Schäfer MK (2012) Functional inactivation of the genome-wide association study obesity gene neuronal growth regulator 1 in mice causes a body mass phenotype. PLoS One 7:e41537.
Boender AJ, van Gestel MA, Garner KM, Luijendijk MC, Adan RA (2014) The obesity-associated gene Negr1 regulates aspects of energy balance in rat hypothalamic areas. Physiol Rep 2:e12083.
Dennis EL, Jahanshad N, Braskie MN, Warstadt NM, Hibar DP, Kohannim O, Nir TM, McMahon KL, de Zubicaray GI, Montgomery GW, Martin NG, Toga AW, Wright MJ, Thompson PM (2014) Obesity gene NEGR1 associated with white matter integrity in healthy young adults. Neuroimage 102 Pt 2:548-557.
Togashi H, Sakisaka T, Takai Y (2009) Cell adhesion molecules in the central nervous system. Cell Adh Migr 3:29-35.
Yamagata M, Sanes JR, Weiner JA (2003) Synaptic adhesion molecules. Curr Opin Cell Biol 15:621-632.
Naseer MI, Rasool M, Chaudhary AG, Sogaty S, Karim S, Schulten HJ, Bibi F, Pushparaj PN, Algahtani HA, Al-Qahtani MH (2017) Chromosomal micro-aberration in a saudi family with juvenile myoclonic epilepsy. CNS Neurol Disord Drug Targets 16:1010-1017.
Tassano E, Gamucci A, Celle ME, Ronchetto P, Cuoco C, Gimelli G (2015) Clinical and molecular cytogenetic characterization of a de novo interstitial 1p31.1p31.3 deletion in a boy with moderate intellectual disability and severe language impairment. Cytogenet Genome Res 146:39-43.
Gamero-Villarroel C, González LM, Gordillo I, Carrillo JA, García-Herráiz A, Flores I, Rodríguez-López R, Gervasini G (2015) Impact of NEGR1 genetic variability on psychological traits of patients with eating disorders. Pharmacogenomics J 15:278-283.
Maccarrone G, Ditzen C, Yassouridis A, Rewerts C, Uhr M, Uhlen M, Holsboer F, Turck CW (2013) Psychiatric patient stratification using biosignatures based on cerebrospinal fluid protein expression clusters. J Psychiatr Res 47:1572-1580.
Amare AT, Schubert KO, Tekola-Ayele F, Hsu YH, Sangkuhl K, Jenkins G, Whaley RM, Barman P, Batzler A, Altman RB, Arolt V, Brockmöller J, Chen CH, Domschke K, Hall-Flavin DK, Hong CJ, Illi A, Ji Y, Kampman O, Kinoshita T, Leinonen E, Liou YJ, Mushiroda T, Nonen S, Skime MK, Wang L, Kato M, Liu YL, Praphanphoj V, Stingl JC, Bobo WV, Tsai SJ, Kubo M, Klein TE, Weinshilboum RM, Biernacka JM, Baune BT (2019) The association of obesity and coronary artery disease genes with response to SSRIs treatment in major depression. J Neural Transm (Vienna) 126:35-45.
Aonurm-Helm A, Jurgenson M, Zharkovsky T, Sonn K, Berezin V, Bock E, Zharkovsky A (2008) Depression-like behaviour in neural cell adhesion molecule (NCAM)-deficient mice and its reversal by an NCAM-derived peptide, FGL. Eur J Neurosci 28:1618-1628.
Tchalla AE, Wellenius GA, Sorond FA, Travison TG, Dantoine T, Lipsitz LA (2015) Elevated circulating vascular cell Adhesion Molecule-1 (sVCAM-1) is associated with concurrent depressive symptoms and cerebral white matter hyperintensities in older adults. BMC Geriatr 15:62.
Wędzony K, Chocyk A, Maćkowiak M (2013) Potential roles of NCAM/PSA-NCAM proteins in depression and the mechanism of action of antidepressant drugs. Pharmacol Rep 65:1471-1478.
Noh K, Lee H, Choi TY, Joo Y, Kim SJ, Kim H, Kim JY, Jahng JW, Lee S, Choi SY, Lee SJ (2019) Negr1 controls adult hippocampal neurogenesis and affective behaviors. Mol Psychiatry 24:1189-1205.
Mucha M, Skrzypiec AE, Schiavon E, Attwood BK, Kucerova E, Pawlak R (2011) Lipocalin-2 controls neuronal excitability and anxiety by regulating dendritic spine formation and maturation. Proc Natl Acad Sci U S A 108:18436-18441.
Ferreira AC, Pinto V, Dá Mesquita S, Novais A, Sousa JC, Correia-Neves M, Sousa N, Palha JA, Marques F (2013) Lipocalin2 is involved in emotional behaviors and cognitive function. Front Cell Neurosci 7:122.
Huyton T, Zhang JG, Luo CS, Lou MZ, Hilton DJ, Nicola NA, Garrett TP (2007) An unusual cytokine:Ig-domain interaction revealed in the crystal structure of leukemia inhibitory factor (LIF) in complex with the LIF receptor. Proc Natl Acad Sci U S A 104:12737-12742.
Ernst M, Inglese M, Waring P, Campbell IK, Bao S, Clay FJ, Alexander WS, Wicks IP, Tarlinton DM, Novak U, Heath JK, Dunn AR (2001) Defective gp130-mediated signal transducer and activator of transcription (STAT) signaling results in degenerative joint disease, gastrointestinal ulceration, and failure of uterine implantation. J Exp Med 194:189-203.
Müller S, Chakrapani BP, Schwegler H, Hofmann HD, Kirsch M (2009) Neurogenesis in the dentate gyrus depends on ciliary neurotrophic factor and signal transducer and activator of transcription 3 signaling. Stem Cells 27:431-441.
Ferreira AC, Novais A, Sousa N, Sousa JC, Marques F (2019) Voluntary running rescues the defective hippocampal neurogenesis and behaviour observed in lipocalin 2-null mice. Sci Rep 9:1649.
Cassano P, Bui E, Rogers AH, Walton ZE, Ross R, Zeng M, Nadal-Vicens M, Mischoulon D, Baker AW, Keshaviah A, Worthington J, Hoge EA, Alpert J, Fava M, Wong KK, Simon NM (2017) Inflammatory cytokines in major depressive disorder:a case-control study. Aust N Z J Psychiatry 51:23-31.
Vogelzangs N, de Jonge P, Smit JH, Bahn S, Penninx BW (2016) Cytokine production capacity in depression and anxiety. Transl Psychiatry 6:e825.
Raghavan NS, Vardarajan B, Mayeux R (2019) Genomic variation in educational attainment modifies Alzheimer disease risk. Neurol Genet 5:e310.
Ni H, Xu M, Zhan GL, Fan Y, Zhou H, Jiang HY, Lu WH, Tan L, Zhang DF, Yao YG, Zhang C (2018) The GWAS risk genes for depression may be actively involved in Alzheimer's disease. J Alzheimers Dis 64:1149-1161.
Karis K, Eskla KL, Kaare M, Täht K, Tuusov J, Visnapuu T, Innos J, Jayaram M, Timmusk T, Weickert CS, Väli M, Vasar E, Philips MA (2018) Altered expression profile of IgLON family of neural cell adhesion molecules in the dorsolateral prefrontal cortex of schizophrenic patients. Front Mol Neurosci 11:8.
Morris RG, Garrud P, Rawlins JN, O'Keefe J (1982) Place navigation impaired in rats with hippocampal lesions. Nature 27:681-683.
Barker GR, Warburton EC (2011) When is the hippocampus involved in recognition memory? J Neurosci 31:1072110731.
Kochli DE, Thompson EC, Fricke EA, Postle AF, Quinn JJ (2015) The amygdala is critical for trace, delay, and contextual fear conditioning. Learn Mem 22:92-100.
Rozeske RR, Valerio S, Chaudun F, Herry C (2015) Prefrontal neuronal circuits of contextual fear conditioning. Genes Brain Behav 14:22-36.
Beeman CL, Bauer PS, Pierson JL, Quinn JJ (2013) Hippocampus and medial prefrontal cortex contributions to trace and contextual fear memory expression over time. Learn Mem 20:336-343.