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Exp Neurobiol 2010; 19(3): 146-154
Published online December 31, 2010
https://doi.org/10.5607/en.2010.19.3.146
© The Korean Society for Brain and Neural Sciences
Jee Youn Lee1,2, Hwang Soo Kim1,2, Tae Hwan Oh1 and Tae Young Yune1,2,3*
1Age-Related and Brain Diseases Research Center, 2Neurodegeneration Control Research Center, 3Department of Biochemistry and Molecular Biology, School of Medicine, Kyung Hee University, Seoul 130-701, Korea
Correspondence to: *To whom correspondence should be addressed.
TEL: 82-2-961-0968, FAX: 82-2-969-6343
e-mail: tyune@khu.ac.kr
Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases that degrade the extracellular matrix and other extracellular proteins. Upregulation of MMPs activity is known to be required for the inflammatory cell infiltration after spinal cord injury (SCI) and most likely contributes to early blood spinal barrier disruption and inflammation, thereby leading to the impairment of functional recovery. Here, we examined the effect of ethanol extract of
Keywords: matrix metalloproteinase, spinal cord injury, blood brain barrier, zymography