• KSBNS 2024


Review Article

Exp Neurobiol 2014; 23(2): 115-123

Published online June 30, 2014

© The Korean Society for Brain and Neural Sciences

Delayed and Prolonged Local Brain Hypothermia Combined with Decompressive Craniectomy: A Novel Therapeutic Strategy That Modulates Glial Dynamics

Jong-Heon Kim1, Sung-Ho Yun2, Kwang-Ho Jang2, Jaechan Park3, Hyung Soo Han4, Dongick Rhee5 and Kyoungho Suk1*

1Department of Pharmacology, Brain Science & Engineering Institute, BK21 Plus KNU Biomedical Convergence Program, Kyungpook National University School of Medicine, Daegu 700-422, 2Department of Surgery, College of Veterinary Medicine, Kyungpook National University, Daegu 702-701, 3Department of Neurosurgery, Kyungpook National University School of Medicine, Daegu 700-721, 4Department of Physiology, Kyungpook National University School of Medicine, Daegu 700-422, 5Kyungwon Medical Co., Ltd., Seoul 135-080, Korea

Correspondence to: *To whom correspondence should be addressed.
TEL: 82-53-420-4835, FAX: 82-53-256-1566

Received: April 28, 2014; Revised: May 22, 2014; Accepted: May 23, 2014


Hypothermia is considered a useful intervention for limiting pathophysiological changes after brain injury. Local hypothermia is a relatively safe and convenient intervention that circumvents many of the complications associated with systemic hypothermia. However, successful hypothermia treatment requires careful consideration of several factors including its practicality, feasibility, and associated risks. Here, we review the protective effects-and the cellular mechanisms that underlie them-of delayed and prolonged local hypothermia in rodent and canine brain injury models. The data show that the protective effects of therapeutic hypothermia, which mainly result from the modulation of inflammatory glial dynamics, are limited. We argue that decompressive craniectomy can be used to overcome the limitations of local brain hypothermia without causing histological abnormalities or other detrimental effects to the cooled area. Therefore, delayed and prolonged local brain hypothermia at the site of craniectomy is a promising intervention that may prove effective in the clinical setting.

Keywords: hypothermia, stroke, traumatic brain injury, astrocyte, microglia, neuroinflammation