• the Korean Society for Brain and Neural Sciences


Review Article

Exp Neurobiol 2014; 23(4): 292-313

Published online December 31, 2014

© The Korean Society for Brain and Neural Sciences

Alpha-Synuclein Function and Dysfunction on Cellular Membranes

David Snead and David Eliezer*

Department of Biochemistry, Weill Cornell Medical College, New York, NY 10065, USA

Correspondence to: *To whom correspondence should be addressed.
TEL: 1-212-746-6557, FAX: 1-212-746-4803

Received: October 1, 2014; Revised: November 15, 2014; Accepted: November 16, 2014


Alpha-synuclein is a small neuronal protein that is closely associated with the etiology of Parkinson's disease. Mutations in and alterations in expression levels of alpha-synuclein cause autosomal dominant early onset heredity forms of Parkinson's disease, and sporadic Parkinson's disease is defined in part by the presence of Lewy bodies and Lewy neurites that are composed primarily of alpha-synuclein deposited in an aggregated amyloid fibril state. The normal function of alpha-synuclein is poorly understood, and the precise mechanisms by which it leads to toxicity and cell death are also unclear. Although alpha-synuclein is a highly soluble, cytoplasmic protein, it binds to a variety of cellular membranes of different properties and compositions. These interactions are considered critical for at least some normal functions of alpha-synuclein, and may well play critical roles in both the aggregation of the protein and its mechanisms of toxicity. Here we review the known features of alpha-synuclein membrane interactions in the context of both the putative functions of the protein and of its pathological roles in disease.

Keywords: alpha-synuclein, Parkinson, amyloid, aggregation, neurotransmission, synucleinopathy