• KSBNS 2024


Original Article

Exp Neurobiol 2015; 24(1): 84-89

Published online March 31, 2015

© The Korean Society for Brain and Neural Sciences

Development of a Touch-Screen-Based Paradigm for Assessing Working Memory in the Mouse

Chuljung Kwak, Chae-Seok Lim and Bong-Kiun Kaang*

Department of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul 151-747, Korea

Correspondence to: *To whom correspondence should be addressed.
TEL: 82-2-880-7525, FAX: 82-2-884-9577


Assessing the working memory of the rodent by using a touch-screen system has several advantages (e.g., allowing highly accurate data collection and flexibility in memory task design). However, there is currently no available testing paradigm utilizing touch-screen systems that can assess working memory in the mouse. In this study, we developed a touch-screen testing paradigm in which mice were trained to choose a location that is matched to a sample location after a time delay. Consistent with previous studies, this study showed that mice could not only learn the rule in the delayed matched to position (DMTP), but also could retain a transitory memory of the sample position during delay. This indicates that a touch-screen system can provide a DMTP testing platform to assess working memory in the mouse.

Keywords: touch screen, working memory, mouse cognition, delayed match to position