• the Korean Society for Brain and Neural Sciences


Review Article

Exp Neurobiol 2015; 24(3): 186-196

Published online September 30, 2015

© The Korean Society for Brain and Neural Sciences

Peripheral Biomarker Candidates of Posttraumatic Stress Disorder

Hee Jin Kang1, Sujung Yoon1* and In Kyoon Lyoo1,2,3

1Ewha Brain Institute, 2Department of Brain and Cognitive Sciences, 3College of Pharmacy, Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul 03760, Korea

Correspondence to: *To whom correspondence should be addressed.
TEL: 82-2-3277-2478, FAX: 82-2-3277-6562

Received: August 20, 2015; Revised: September 10, 2015; Accepted: September 10, 2015


There is high variability in the manifestation of physical and mental health problems following exposure to trauma and disaster. Although most people may show a range of acute symptoms in the aftermath of traumatic events, chronic and persistent mental disorders may not be developed in all individuals who were exposed to traumatic events. The most common long-term pathological consequence after trauma exposure is posttraumatic stress disorder (PTSD). However, comorbid conditions including depression, anxiety disorder, substance use-related problems, and a variety of other symptoms may frequently be observed in individuals with trauma exposure. Post-traumatic syndrome (PTS) is defined collectively as vast psychosocial problems that could be experienced in response to traumatic events. It is important to predict who will continue to suffer from physical and mental health problems and who will recover following trauma exposure. However, given the heterogeneity and variability in symptom manifestations, it is difficult to find identify biomarkers which predict the development of PTSD. In this review, we will summarize the results of recent studies with regard to putative biomarkers of PTSD and suggest future research directions for biomarker discovery for PTSD.

Keywords: posttraumatic stress disorder (PTSD), posttraumatic syndrome (PTS), biomarkers, neuroendocrine system, inflammation, neurotransmission