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Exp Neurobiol 2016; 25(2): 55-63
Published online April 30, 2016
https://doi.org/10.5607/en.2016.25.2.55
© The Korean Society for Brain and Neural Sciences
Ji-il Kim1, Hye-Yeon Cho2, Jin-Hee Han2 and Bong-Kiun Kaang1*
1Department of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul 08826, 2Department of Biological Sciences, KAIST Institute for the BioCentury (KIB), Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Korea
Correspondence to: *To whom correspondence should be addressed.
TEL: 82-2-880-9024, FAX: 82-2-884-9577
e-mail: kaang@snu.ac.kr
During past decades, the formation and storage principle of memory have received much attention in the neuroscience field. Although some studies have attempted to demonstrate the nature of the engram, elucidating the memory engram allocation mechanism was not possible because of the limitations of existing methods, which cannot specifically modulate the candidate neuronal population. Recently, the development of new techniques, which offer ways to mark and control specific populations of neurons, may accelerate solving this issue. Here, we review the recent advances, which have provided substantial evidence showing that both candidates (neuronal population that is activated by learning, and that has increased CREB level/excitability at learning) satisfy the criteria of the engram, which are necessary and sufficient for memory expression.
Keywords: Memory engram, excitability, CREB, Memory allocation, Review