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Case Report

Exp Neurobiol 2016; 25(2): 93-101

Published online April 30, 2016

© The Korean Society for Brain and Neural Sciences

Fractionated Stereotactic Gamma Knife Radiosurgery for Medial Temporal Lobe Epilepsy: A Case Report

Hye Ran Park1,3, Hyun-Tai Chung1, Sang Kun Lee2, Dong Gyu Kim1 and Sun Ha Paek1*

Department of 1Neurosurgery, 2Neurology, Seoul National University Hospital, Seoul 03080, 3Department of Neurosurgery, Soonchunhyang University Seoul Hospital, Seoul 04401, Korea

Correspondence to: *To whom correspondence should be addressed.
TEL: 82-2-2072-3993, 82-2-2072-3957, FAX: 82-2-744-8459, 82-2-747-3799

Received: January 22, 2016; Revised: January 22, 2016; Accepted: January 23, 2016


An 18-year-old left-handed male harbored intractable medial temporal lobe epilepsy (MTLE) underwent fractionated gamma knife surgery (GKS) instead of open surgery, considering the mental retardation and diffuse cerebral dysfunction. GKS treatment parameters were: target volume, 8.8 cm3; total marginal dose, 24 Gy in 3 fractionations at the 50% isodose line. The patient has been free from seizures since 9 months after GKS, with notable improvement in cognitive outcome. Fractionated GKS could be considered as a safe tool for seizure control and neuropsychological improvement in patients with MTLE.

Keywords: Radiosurgery, Stereotaxic Techniques, Epilepsy