Exp Neurobiol 2016; 25(6): 296-306
Published online December 31, 2016
© The Korean Society for Brain and Neural Sciences
Yoonhee Kim1†, Yinhua Zhang1†, Kaifang Pang2,3†, Hyojin Kang4, Heejoo Park5, Yeunkum Lee1, Bokyoung Lee1, Heon-Jeong Lee6, Won-Ki Kim1, Dongho Geum5 and Kihoon Han1*
1Department of Neuroscience and Division of Brain Korea 21 Biomedical Science, Korea University College of Medicine, Seoul 02841, Korea, 2Jan and Dan Duncan Neurological Research Institute at Texas Children’s Hospital, 3Department of Pediatrics, Computational and Integrative Biomedical Research Center, Baylor College of Medicine, Houston 77030, USA, 4HPC-enabled Convergence Technology Research Division, Korea Institute of Science and Technology Information, Daejeon 34141, 5Department of Biomedical Sciences, Korea University College of Medicine, 6Department of Psychiatry, Korea University College of Medicine, Seoul 02841, Korea
Correspondence to: *To whom correspondence should be addressed.
TEL: 82-2-2286-1390, FAX: 82-2-953-6095
†These authors contributed equally to this work.
Bipolar disorder (BD), characterized by recurrent mood swings between depression and mania, is a highly heritable and devastating mental illness with poorly defined pathophysiology. Recent genome-wide molecular genetic studies have identified several protein-coding genes and microRNAs (miRNAs) significantly associated with BD. Notably, some of the proteins expressed from BD-associated genes function in neuronal synapses, suggesting that abnormalities in synaptic function could be one of the key pathogenic mechanisms of BD. In contrast, however, the role of BD-associated miRNAs in disease pathogenesis remains largely unknown, mainly because of a lack of understanding about their target mRNAs and pathways in neurons. To address this problem, in this study, we focused on a recently identified BD-associated but uncharacterized miRNA, miR-1908-5p. We identified and validated its novel target genes including
Keywords: Bipolar disorder, microRNA, miR-1908-5p, glutamatergic synapse