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Rapid Communication

Exp Neurobiol 2016; 25(6): 342-346

Published online December 31, 2016

© The Korean Society for Brain and Neural Sciences

Mildly Increased Mechanical Nociceptive Sensitivity in REV-ERBα Knock-out Mice

Jaehyun Lee1, Hyoung-Gon Ko1, Kyungjin Kim2 and Bong-Kiun Kaang1*

1Department of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul 08826, 2Department of Brain and Cognitive Science, DGIST, Daegu 42988, Korea

Correspondence to: *To whom correspondence should be addressed.
TEL: 82-2-880-7525, FAX: 82-2-884-9577
e-mail: kaang@

Received: August 13, 2016; Revised: October 28, 2016; Accepted: November 9, 2016


Nociception is one of the most complex senses that is affected not only by external stimulation but also internal conditions. Previous studies have suggested that circadian rhythm is important in modulating nociception. REV-ERBα knock-out (KO) mice have disrupted circadian rhythm and altered mood-related phenotypes. In this study, we examined the role of REV-ERBα in inflammatory nociception. We found that the nociceptive sensitivity of KO mice was partially enhanced in mechanical nociception. However, this partial alteration was independent of the circadian rhythm. Taken together, deletion of REV-ERBα induced a mild change in mechanical nociceptive sensitivity but this alteration was not dependent on the circadian rhythm.

Keywords: Circadian rhythm, REV-ERBα, Nociception, Inflammatory pain