• KSBNS 2024


Original Article

Exp Neurobiol 2017; 26(2): 90-96

Published online April 30, 2017

© The Korean Society for Brain and Neural Sciences

Pulse-train Stimulation of Primary Somatosensory Cortex Blocks Pain Perception in Tail Clip Test

Soohyun Lee1,2†, Eunjin Hwang1†, Dongmyeong Lee3 and Jee Hyun Choi1,4*

1Center for Neuroscience, Korea Institute of Science and Technology, Seoul 02792, 2Department of Physics, Pohang University of Science and Technology, Pohang 37673, 3Center for Cognition and Sociality, Institute of Basic Science, Daejeon 34047, 4Department of Neuroscience, University of Science and Technology, Daejeon 34113, Korea

Correspondence to: *To whom correspondence should be addressed.
TEL: 82-2-958-6952, FAX: 82-2-958-6937
These authors contributed equally to this work.

Received: March 14, 2017; Revised: March 31, 2017; Accepted: April 1, 2017


Human studies of brain stimulation have demonstrated modulatory effects on the perception of pain. However, whether the primary somatosensory cortical activity is associated with antinociceptive responses remains unknown. Therefore, we examined the antinociceptive effects of neuronal activity evoked by optogenetic stimulation of primary somatosensory cortex. Optogenetic transgenic mice were subjected to continuous or pulse-train optogenetic stimulation of the primary somatosensory cortex at frequencies of 15, 30, and 40 Hz, during a tail clip test. Reaction time was measured using a digital high-speed video camera. Pulse-train optogenetic stimulation of primary somatosensory cortex showed a delayed pain response with respect to a tail clip, whereas no significant change in reaction time was observed with continuous stimulation. In response to the pulse-train stimulation, video monitoring and local field potential recording revealed associated paw movement and sensorimotor rhythms, respectively. Our results show that optogenetic stimulation of primary somatosensory cortex at beta and gamma frequencies blocks transmission of pain signals in tail clip test.

Keywords: optogenetic stimulation, tail clip test, sensorimotor rhythms, primary somatosensory cortex, pain perception