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Exp Neurobiol 2018; 27(6): 550-563
Published online December 12, 2018
https://doi.org/10.5607/en.2018.27.6.550
© The Korean Society for Brain and Neural Sciences
Keunjung Heo1,†, Su Min Lim2,†, Minyeop Nahm2,†, Young-Eun Kim3, Ki-Wook Oh2, Hwan Tae Park4, Chang-Seok Ki5*, Seung Hyun Kim2*, and Seungbok Lee1*
1Department of Brain and Cognitive Sciences and Dental Research Institute, Seoul National University, Seoul 08826, Korea.
2Department of Neurology, College of Medicine, Hanyang University, Seoul 04763, Korea.
3Department of Laboratory Medicine, College of Medicine, Hanyang University, Seoul 04763, Korea.
4Department of Molecular Neuroscience, College of Medicine, Dong-A University, Busan 49201, Korea.
5Green Cross Genome Corporation, Yongin 16924, Korea.
Correspondence to: *To whom correspondence should be addressed.
Chang-Seok Ki, TEL: 82-31-260-0601, FAX: 82-31-260-9087, e-mail: changski.md@gmail.com
Seung Hyun Kim, TEL: 82-2-2290-8371, FAX: 82-2-2296-8370, e-mail: kimsh1@hanyang.ac.kr
Seungbok Lee, TEL: 82-2-880-2330, FAX: 82-2-762-2583, e-mail: seunglee@snu.ac.kr
†
These authors contributed equally to this work.
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that is frequently linked to microtubule abnormalities and mitochondrial trafficking defects. Whole exome sequencing (WES) of patient-parent trios has proven to be an efficient strategy for identifying rare
Keywords: Amyotrophic lateral sclerosis, Whole exome sequencing,