• KSBNS 2024


Original Article

Exp Neurobiol 2019; 28(1): 43-53

Published online January 30, 2019

© The Korean Society for Brain and Neural Sciences

14-3-3γ Haploinsufficient Mice Display Hyperactive and Stress-sensitive Behaviors

Do Eon Kim1,†, Chang-Hoon Cho2,†, Kyoung Mi Sim2, Osung Kwon2, Eun Mi Hwang3, Hyung-Wook Kim1*, and Jae-Yong Park2*

1College of Life Sciences, Sejong University, Seoul 05006, Korea.

2School of Biosystem and Biomedical Science, College of Health Science, Korea University, Seoul 02708, Korea.

3Center for Functional Connectomics, Korea Institute of Science and Technology (KIST), Seoul 02792, Korea.

Correspondence to: *To whom correspondence should be addressed.
Jae-Yong Park, TEL: 82-2-3290-5637, FAX: 82-2-917-2388
Hyung-Wook Kim, TEL: 82-2-3408-3202, FAX: 82-2-3408-4334
These authors contribute equally for this study

Received: December 9, 2018; Revised: January 16, 2019; Accepted: January 18, 2019

14-3-3γ plays diverse roles in different aspects of cellular processes. Especially in the brain where 14-3-3γ is enriched, it has been reported to be involved in neurological and psychiatric diseases (e.g. Williams-Beuren syndrome and Creutzfeldt-Jakob disease). However, behavioral abnormalities related to 14-3-3γ deficiency are largely unknown. Here, by using 14-3-3γ deficient mice, we found that homozygous knockout mice were prenatally lethal, and heterozygous mice showed developmental delay relative to wild-type littermate mice. In addition, in behavioral analyses, we found that 14-3-3γ heterozygote mice display hyperactive and depressive-like behavior along with more sensitive responses to acute stress than littermate control mice. These results suggest that 14-3-3γ levels may be involved in the developmental manifestation of related neuropsychiatric diseases. In addition, 14-3-3γ heterozygote mice may be a potential model to study the molecular pathophysiology of neuropsychiatric symptoms.

Graphical Abstract

Keywords: 14-3-3γ, Ywhag, Hyperactivity, Anxiety, Acute stress, ADHD