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Review Article

Exp Neurobiol 2019; 28(2): 146-157

Published online April 8, 2019

© The Korean Society for Brain and Neural Sciences

Assessment of Cognitive Phenotyping in Inbred, Genetically Modified Mice, and Transgenic Mouse Models of Alzheimer's Disease

Dong-Hee Kim1, Yoon-Sun Jang1, Won Kyung Jeon2,3, and Jung-Soo Han1*

1Department of Biological Sciences, Konkuk University, Seoul 05029, Korea.

2Herbal Medicine Research Division, Korea Institute of Oriental Medicine, Daejeon 34054, Korea.

3Convergence Research Center for Diagnosis, Treatment and Care System of Dementia, Korea Institute of Science and Technology, Seoul 02792, Korea.

Correspondence to: *To whom correspondence should be addressed.
TEL: 82-2-450-3293, FAX: 82-2-3436-5432

Received: February 2, 2019; Revised: March 18, 2019; Accepted: March 25, 2019

Genetically modified mouse models are being used predominantly to understand brain functions and diseases. Well-designed and controlled behavioral analyses of genetically modified mice have successfully led to the identification of gene functions, understanding of brain diseases, and development of treatments. Recently, complex and higher cognitive functions have been examined in mice with genetic mutations. Therefore, research strategies for cognitive phenotyping should be sophisticated and evolve to convey the exact meaning of the findings and provide robust translational tools for testing hypotheses and developing treatments. This review addresses issues of experimental design and discusses studies that have examined cognitive function using mouse strain differences, genetically modified mice, and transgenic mice for Alzheimer's disease.

Graphical Abstract

Keywords: Hippocampus, Mice, Water maze, Fear conditioning, Object recognition, Prefrontal cortex