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Article
Original Article
Exp Neurobiol 2020; 29(1): 11-26
Published online February 29, 2020
https://doi.org/10.5607/en.2020.29.1.11
© The Korean Society for Brain and Neural Sciences
Distribution of Cadherin in the Parahippocampal Area of Developing Domestic Chicken Embryos
He Zhou1,2, XiaoFan Wang1, JunTang Lin3, Ze Zhao4 and Cheng Chang1,5,6*
1School of Basic Medical Sciences, ZhengZhou University, Zhengzhou 450000, China, 2Department of General and Visceral Surgery, Goethe-University Hospital, Frankfurt am Main 60596, Germany, 3Henan Joint International Research Laboratory of Stem Cell Medicine, College of Biomedical Engineering, Xinxiang Medical University, Xinxiang 453000, 4School of Law, Shanghai University of Finance and Economics, Shanghai 200000, 5Birth Defect Prevention Key Laboratory, National Health Commission of the People’s Republic of China, Zhengzhou 450000, 6Center of Cerebral Palsy Surgical Research and Treatment, ZhengZhou University, Zhengzhou 450000, China
Correspondence to: *To whom correspondence should be addressed.
TEL: 86-13838257005, FAX: 86-37167781979, 450001
e-mail: changcheng@zzu.edu.cn
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License
(http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and
reproduction in any medium, provided the original work is properly cited.
Abstract
Hippocampal formation is important in spatial learning and memory. Members of the cadherin superfamily are observed in the neural system with diverse spatial and temporal expression patterns and are involved in many biological processes. To date, the avian hippocampal formation is not well understood. In this study, we examined the expression of cadherin mRNA in chicken and mouse brains to investigate the morphological and cytoarchitectural bases of hippocampal formation. Profiles of the spatiotemporal expression of cadherin mRNAs in the developing chicken embryonic parahippocampal area (APH) are provided, and layer-specific expression and spatiotemporal expression were observed in different subdivisions of the APH. That fact that some cadherins (Cdh2, Cdh8, Pcdh8 and Pcdh10) showed conserved regional expression both in the hippocampus and entorhinal cortex of mice and the hippocampal formation of chickens partially confirmed the structural homology proposed by previous scientists. This study indicates that some cadherins can be used as special markers of the avian hippocampal formation.
Graphical Abstract
Keywords: Hippocampus, Parahippocampal area, Cadherin, Chicken embryos, Avian
