Exp Neurobiol 2020; 29(4): 300-313
Published online August 31, 2020
© The Korean Society for Brain and Neural Sciences
Jinyoung Won1†, Kyung Sik Yi2†, Chi-Hoon Choi2†, Chang-Yeop Jeon1†, Jincheol Seo1, Keonwoo Kim1,3, Hyeon-Gu Yeo1,4, Junghyung Park1, Yu Gyeong Kim1,4, Yeung Bae Jin1, Bon-Sang Koo1, Kyung Seob Lim5, Sangil Lee1, Ki Jin Kim1, Won Seok Choi1, Sung-Hyun Park1, Young-Hyun Kim1,4, Jae-Won Huh1,4, Sang-Rae Lee1,4, Sang-Hoon Cha2* and Youngjeon Lee1,4*
1National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju 28116, 2Department of Radiology, Chungbuk National University Hospital, Cheongju 28644, 3School of Life Sciences, BK21 Plus KNU Creative BioResearch Group, Kyungpook National University, Daegu 41566, 4Department of Functional Genomics, KRIBB School of Bioscience, Korea University of Science and Technology, Daejeon 34113, 5Futuristic Animal Resource & Research Center, KRIBB, Cheongju 28116, Korea
Correspondence to: *To whom correspondence should be addressed.
Youngjeon Lee, TEL: 82-43-240-6316, FAX: 82-43-240-6309
Sang-Hoon Cha, TEL: 82-43-269-6473, FAX: 82-43-269-6479
†These authors contributed equally to this work.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License
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Ischemic stroke results from arterial occlusion and can cause irreversible brain injury. A non-human primate (NHP) model of ischemic stroke was previously developed to investigate its pathophysiology and for efficacy testing of therapeutic candidates; however, fine motor impairment remains to be well-characterized. We evaluated hand motor function in a cynomolgus monkey model of ischemic stroke. Endovascular transient middle cerebral artery occlusion (MCAO) with an angiographic microcatheter induced cerebral infarction.