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Original Article
Exp Neurobiol 2020; 29(5): 376-388
Published online October 31, 2020
https://doi.org/10.5607/en20040
© The Korean Society for Brain and Neural Sciences
Impaired Hand Dexterity Function in a Non-human Primate Model with Chronic Parkinson’s Disease
Jincheol Seo1,2†, Jinyoung Won1†, Keonwoo Kim1,2†, Junghyung Park1, Hyeon-Gu Yeo1,3, Yu Gyeong Kim1,3, Seung Ho Baek1, Hoonwon Lee4, Chang-Yeop Jeon1, Won Seok Choi1, Sangil Lee5, Ki Jin Kim5, Sung-Hyun Park1, Yeonghoon Son5, Kang Jin Jeong1, Kyung Seob Lim6, Philyong Kang6, Hwal-Yong Lee6, Hee-Chang Son6, Jae-Won Huh1,3, Young-Hyun Kim1,3, Dong-Seok Lee2, Sang-Rae Lee1,3, Ji-Woong Choi7,8* and Youngjeon Lee1,3*
1National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju 28116, 2School of Life Sciences, BK21 Plus KNU Creative BioResearch Group, Kyungpook National University, Daegu 41566, 3Department of Functional Genomics, KRIBB School of Bioscience, Korea University of Science and Technology, Daejeon 34113, 4School of Biological Sciences, Seoul National University, Seoul 08826, 5Primate Resource Center, KRIBB, Jeongeup 56216, 6Futuristic Animal Resource & Research Center, KRIBB, Cheongju 28116, 7Brain Engineering Convergence Research Center, Daegu Gyeongbuk Institute of Science & Technology (DGIST), Daegu 42988, 8Department of Information and Communication Engineering, DGIST, Daegu 42988, Korea
Correspondence to: *To whom correspondence should be addressed.
Youngjeon Lee, TEL: 82-43-240-6316, FAX: 82-43-240-6309
e-mail: neurosci@kribb.re.kr
Ji-Woong Choi, TEL: 82-53-785-6311, FAX: 82-53-785-6309
e-mail: jwchoi@dgist.ac.kr
†These authors contributed equally to this work.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Symptoms of Parkinson’s disease (PD) caused by loss of dopaminergic neurons are accompanied by movement disorders, including tremors, rigidity, bradykinesia, and akinesia. Non-human primate (NHP) models with PD play an essential role in the analysis of PD pathophysiology and behavior symptoms. As impairments of hand dexterity function can affect activities of daily living in patients with PD, research on hand dexterity function in NHP models with chronic PD is essential. Traditional rating scales previously used in the evaluation of animal spontaneous behavior were insufficient due to factors related to subjectivity and passivity. Thus, experimentally designed applications for an appropriate apparatus are necessary. In this study, we aimed to longitudinally assess hand dexterity function using hand dexterity task (HDT) in NHP-PD models. To validate this assessment, we analyzed the alteration in Parkinsonian tremor signs and the functionality of presynaptic dopaminergic neuron using positron emission tomography imaging of dopamine transporters in these models. In addition, a significant inverse correlation between HDT and DAT level was identified, but no local bias was found. The correlation with intention tremor signs was lower than the resting tremor. In conclusion, the evaluation of HDT may reflect behavioral symptoms of NHP-PD models. Furthermore, HDT was effectively used to experimentally distinguish intention tremors from other tremors.
Graphical Abstract
Keywords: Parkinson's disease, Non-human primate, Hand dexterity function, Hand dexterity task, Tremor
