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Article
Original Article
Exp Neurobiol 2021; 30(4): 308-317
Published online August 31, 2021
https://doi.org/10.5607/en21011
© The Korean Society for Brain and Neural Sciences
Attenuation of Experimental Autoimmune Uveitis in Lewis Rats by Betaine
Yuna Choi1, Kyungsook Jung2, Hyo Jin Kim3, Jiyoon Chun1, Meejung Ahn4, Youngheun Jee1, Hyun Ju Ko1, Changjong Moon5, Hiroshi Matsuda6, Akane Tanaka6, Jeongtae Kim7* and Taekyun Shin1*
1College of Veterinary Medicine and Veterinary Medical Research Institute, Jeju National University, Jeju 63243, 2Functional Biomaterials Research Center, Korea Research Institute of Bioscience and Biotechnology, Jeongeup 56212, 3Department of Food Bioengineering, Jeju National University, Jeju 63243, 4Department of Animal Science, College of Life Science, Sangji University, Wonju 26339, 5Department of Veterinary Anatomy and Animal Behavior, College of Veterinary Medicine and BK21 Plus Project Team, Chonnam National University, Gwangju 61186, Korea, 6Laboratory of Veterinary Molecular Pathology and Therapeutics, Division of Animal Life Science, Graduate School, Institute of Agriculture, Tokyo University of Agriculture and Technology, Tokyo 183-8509, Japan, 7Department of Anatomy, Kosin University College of Medicine, Busan 49267, Korea
Correspondence to: *To whom correspondence should be addressed.
Taekyun Shin, TEL: 82-64-754-3363, FAX: 82-64-756-3354
e-mail: shint@jejunu.ac.kr
Jeongtae Kim, TEL: 82-51-990-6412, FAX: 82-51-241-5458
e-mail: kimjt78@kosin.ac.kr
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Experimental autoimmune uveitis (EAU) is an animal model of human autoimmune uveitis that is characterized by the infiltration of autoimmune T cells with concurrent increases in pro-inflammatory cytokines and reactive oxygen species. This study aimed to assess whether betaine regulates the progression of EAU in Lewis rats. EAU was induced via immunization with the interphotoreceptor retinoid-binding protein (IRBP) and oral administration of either a vehicle or betaine (100 mg/kg) for 9 consecutive days. Spleens, blood, and retinas were sampled from the experimental rats at the time of sacrifice and used for the T cell proliferation assay, serological analysis, real-time polymerase chain reaction, and immunohistochemistry. The T cell proliferation assay revealed that betaine had little effect on the proliferation of splenic T cells against the IRBP antigen in an
Graphical Abstract
Keywords: Anti-inflammation, Anti-oxidation, Betaine, Experimental autoimmune uveitis, Retina
