Articles

Article

Original

Exp Neurobiol 2008; 17(1): 7-10

Published online June 30, 2008

© The Korean Society for Brain and Neural Sciences

A Polymorphism of Fibrinogen Beta Chain (FGB) Gene is Not Associated with Autistic Spectrum Disorder in Korean Population

Shihwan Chang1, Ah Rang Cho1,2, Bum Shik Kim1,3, and Joo-Ho Chung1*

1Kohwang Medical Research Institute, Department of Pharmacology, School of Medicine, 2Department of Neuropsychiatry, 3Department of Thoracic and Cardiovascular Surgery, Kyung Hee University, Seoul 130-701, Korea

Correspondence to: *To whom correspondence should be addressed.
TEL: 82-2-961-0281, FAX: 82-2-968-0560
e-mail: jhchung@khu.ac.kr

Abstract

Evidences has been accumulated the difference of cardiovascular phenotypes in autistic spectrum disorder (ASD). To determine the genetic association between fibrinogen beta chain (FGB) gene and ASD in Korean population, we genotyped single nucleotide polymorphism (SNP) (rs4220, Arg478Lys, exon 8) in the FGB gene by using direct sequencing. Among nonsynonymous SNPs in the coding region of FGB, only one SNP's heterozygosity (rs4220) is more than 0.05. Therefore, we analyzed the association between rs4220 and ASD. Three hundred six control and 196 ASD subjects were evaluated. For the analysis of genetic data, SNPStats, SNPAnalyzer, and Helixtree programs were used. Multiple logistic regression analysis (codominant, dominant, and recessive models) was also used. The result showed that a SNP (rs4220) in the FGB gene was not significantly difference between ASD and controls in three alternative models. This result suggests that the FGB gene may have no relation to the development of ASD.

Keywords: association, autistic spectrum disorder, fibrinogen beta chain, single nucleotide polymorphism