Articles

Article

Original Article

Exp Neurobiol 2008; 17(2): 63-69

Published online December 31, 2008

© The Korean Society for Brain and Neural Sciences

Protective Effect of Orally Administrated Dandelion Against Carrageenan-induced Ankle Arthritis in Rats

Bong-Jun Sur1, Yoon-Jeong Koh2, Hee-Don Choi2, Insop Shim3, Hyejung Lee1, Dae-Hyun Hahm1*

1Acupuncture & Meridian Science Research Center, Kyunghee University, Seoul 130-701, 2Korea Food Research Institute, Seongnam 463-746, 3Department of Integrative Medicine, The Catholic University of Korea, College of Medicine, Seoul 137-701, Korea

Correspondence to: *To whom correspondence should be addressed.
TEL: 02-961-0366, FAX: 02-966-2175
e-mail: dhhahm@khu.ac.kr

Abstract

Dandelion (DA) possesses the therapeutic ability to eliminate heat and alleviating swelling, choleresis, dieresis, and inflammation. In order to investigate the anti-arthritic effect of DA, several behavioral parameters such as paw volume, squeaking score, and weight distribution ratio were investigated in a carrageenan-induced arthritis rat model. At the maximum severity of arthritis, the daily administration of DA was initiated and lasted for 9 days. The therapeutic effects of DA were observed on 9th day after the arthritis induction, as compared to saline-treated control group. Oral administration of DA significantly alleviated apparent symptoms of paw volume, squeaking score, and weight distribution ratio in rats. In conclusion, DA was found to be effective in alleviating the inflammatory response and thus arthritic symptoms in carrageenan-induced arthritic rats.

Keywords: dandelion, arthritis, carrageenan, paw volume, squeaking score, weight distribution ratio