• KSBNS 2024


Original Article

Exp Neurobiol 2009; 18(1): 62-65

Published online June 30, 2009

© The Korean Society for Brain and Neural Sciences

Sustained Expression of Neuritin mRNA After Repeated Electroconvulsive Stimulations in the Rat Hippocampal Formation

Kun Woo Park2, Il Hwan Kim1, Woong Sun1 and Hyun Kim1*

1Department of Anatomy, Brain Korea 21, 2Department of Neurology, College of Medicine, Korea University, Seoul 136-705, Korea

Correspondence to: *To whom correspondence should be addressed.
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In the present study, we compared the expression patterns of neuritin mRNA in the dentate gyrus of hippocampal formation following single (1×ECS) or repeated elctroconvulsive seizures (8×ECS) treatments to the rat. The expression of neuritin mRNA was transiently increased, and returned to basal level within 12 hours after 1×ECS. Whereas initial induction of neuritin mRNA was similarly seen, these increased mRNA level was maintained for 24 hours in 8×ECS group. In contrast, induction profile of BDNF was similar following 1× and 8×ECS. These results suggest that regulation of neuritin expression may be plastically changed by repeated ECS treatment.

Keywords: neuritin, elctroconvulsive seizure (ECS), neuronal plasticity, dentate gyrus