Exp Neurobiol 2009; 18(1): 62-65
Published online June 30, 2009
© The Korean Society for Brain and Neural Sciences
Kun Woo Park2, Il Hwan Kim1, Woong Sun1 and Hyun Kim1*
1Department of Anatomy, Brain Korea 21, 2Department of Neurology, College of Medicine, Korea University, Seoul 136-705, Korea
Correspondence to: *To whom correspondence should be addressed.
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In the present study, we compared the expression patterns of neuritin mRNA in the dentate gyrus of hippocampal formation following single (1×ECS) or repeated elctroconvulsive seizures (8×ECS) treatments to the rat. The expression of neuritin mRNA was transiently increased, and returned to basal level within 12 hours after 1×ECS. Whereas initial induction of neuritin mRNA was similarly seen, these increased mRNA level was maintained for 24 hours in 8×ECS group. In contrast, induction profile of BDNF was similar following 1× and 8×ECS. These results suggest that regulation of neuritin expression may be plastically changed by repeated ECS treatment.
Keywords: neuritin, elctroconvulsive seizure (ECS), neuronal plasticity, dentate gyrus