Articles

Article

Original Article

Exp Neurobiol 2009; 18(2): 123-128

Published online December 31, 2009

© The Korean Society for Brain and Neural Sciences

Neuroprotective Effect of Fucoidan against N-methyl-D-aspartate-Induced Excitotoxicity in Rat Hippocampus

Young-Joon Ha1, Youn-Sub Kim1, Hye-Jung Lee2, Jin-Hee Seo3, Yun-Hee Sung3, Sung-Eun Kim3, Mal-Soon Shin3 and Chang-Ju Kim3*

1Department of Anatomy-Meridian, College of Oriental Medicine, Kyungwon University, Sungnam 461-701, 2Acupuncture and Meridian Science Research Center, Kyung Hee University, 3Department of Physiology, College of Medicine, Kyung Hee University, Seoul 130-701, Korea

Correspondence to: *To whom correspondence should be addressed.
TEL: 82-2-961-0407, FAX: 82-2-964-2195
e-mail: changju@khu.ac.kr

Abstract

Fucoidan, a sulfated polyanionic polymer of L-fucose, is obtained from brown marine macroalgae. In the present study, neuroprotective effect of fucoidan against N-methyl- D-aspartate (NMDA)-induced excitotoxicity in the hippocampus was investigated. The patch clamp study revealed that fucoidan significantly inhibited NMDA receptor-activated ion current in the acutely dissociated hippocampal CA1 neurons. In an organotypic hippocampal slice culture, fucoidan inhibited NMDA-induced neuronal cell death in a dose-dependent manner. The present study showed that fucoidan possesses a neuroprotective effect against NMDA-induced excitotoxicity, and that the suppressive effect of fucoidan on the NMDA-induced ion current can be suggested as being the underlying neuroprotective mechanism of fucoidan.

Keywords: fucoidan, N-methyl-D-aspartate, hippocampus, patch clamp, slice culture