Exp Neurobiol 2015; 24(1): 55-70

Published online March 31, 2015

https://doi.org/10.5607/en.2015.24.1.55

© The Korean Society for Brain and Neural Sciences

COMP-Ang1 Potentiates EPC Treatment of Ischemic Brain Injury by Enhancing Angiogenesis Through Activating AKT-mTOR Pathway and Promoting Vascular Migration Through Activating Tie2-FAK Pathway

Hyo Eun Moon^1,2,3#, Kyunghee Byun^4,5#, Hyung Woo Park^1,2,3, Jin Hyun Kim⁶, Jin Hur⁷, Joong Shin Park⁸, Jong Kwan Jun⁸, Hyo-Soo Kim⁷, Seung Leal Paek^1,2,3,9, In Keyoung Kim¹, Jae Ha Hwang¹, Jin Wook Kim¹, Dong Gyu Kim¹, Young Chul Sung¹⁰, Gou-Young Koh¹¹, Chang W Song¹², Bonghee Lee^4,5* and Sun Ha Paek^1,2,3*

¹Department of Neurosurgery, ²Cancer Research Institute, ³Ischemic/Hypoxic Disease Institute, Seoul National University College of Medicine, Seoul 110-744^{, 4}Center for Regenerative Medicine, Lee Gil Ya Cancer and Diabetes Institute, Gachon University, ⁵Department of Anatomy and Cell Biology, Gachon University Medical School, Incheon 406-840, ⁶Clinical Research Institute, Gyeongsang National University Hospital, Jinju 660-702^{, 7}Innovative Research Institute for Cell Therapy (IRICT), Seoul National University Hospital, ⁸Department of Obstetrics & Gynecology, Seoul National University Hospital, Seoul 110-744, Korea, ⁹Department of Neurosurgery, Mayo Clinic, USA, ¹⁰Division of Molecular and Life Science, Integrative Bioscience & Biotechnology, Pohang University of Science and Technology, Pohang 790-784, ¹¹Laboratory for Vascular Biology and Stem Cell, Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 305-338, Korea, ¹²Department of Therapeutic Radiology-Radiation Oncology, University of Minnesota Medical School, Minneapolis, USA

Correspondence to: ^*To whom correspondence should be addressed.
Sun Ha Paek, TEL: 82-2-2072-3993, FAX: 82-2-744-8459, e-mail: paeksh@snu.ac.kr
Bonghee Lee, TEL: 82-32-899-6582, FAX: 82-32-899-6519, e-mail: bhlee@gachon.ac.kr
^#These authors equally contributed to this work.