Articles

Article

Original Article

Exp Neurobiol 2015; 24(1): 8-16

Published online March 31, 2015

https://doi.org/10.5607/en.2015.24.1.8

© The Korean Society for Brain and Neural Sciences

A Critical Role of GIT1 in Vertebrate and Invertebrate Brain Development

Sung-Tae Hong1 and Won Mah1,2*

1Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 2Department of Anatomy and Neurobiology, School of Dentistry, Kyungpook National University, Daegu, Korea

Correspondence to: *To whom correspondence should be addressed.
TEL: 82-53-660-6861, FAX: 82-53-426-7731
e-mail: Wonmah@knu.ac.kr

Received: February 11, 2015; Revised: February 14, 2015; Accepted: February 14, 2015

Abstract

GIT1, a multifunctional signaling adaptor protein, is implicated in the development of dendritic spines and neuronal synapses. GIT1 forms a signaling complex with PIX, RAC, and PAK proteins that is known to play important roles in brain development. Here we found that Git1-knockout (Git1-/-) mice show a microcephaly-like small brain phenotype, which appears to be caused by reduced neuronal size rather than number. Git1-/- mice also show decreased dendritic spine number without morphological alterations in the hippocampus. Behaviorally, Git1-/- mice show impaired motor coordination and learning and memory. In addition, adult dGit Drosophila mutants show decreased brain size and abnormal morphology of the mushroom body. These results suggest that GIT1 is important for brain development in both rodents and flies.

Keywords: GIT1, dGit, Microcephaly, Brain Development