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Exp Neurobiol 2016; 25(1): 48-54
Published online February 29, 2016
https://doi.org/10.5607/en.2016.25.1.48
© The Korean Society for Brain and Neural Sciences
Heeyoung An1,2, Doo-Wan Cho3, Seung Eun Lee1, Young-Su Yang3,Su-Cheol Han3* and C. Justin Lee1,2*
1Center for Neuroscience and Functional Connectomics, Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul 02792, 2KU-KIST School of Converging Science and Technology, Korea University, Seoul 02841, 3General Toxicology Research Center, Jeonbuk Department of Inhalation Research, Korea Institute of Toxicology, KRICT, Jeongeup 56212, Korea
Correspondence to: *To whom correspondence should be addressed.
TEL: 82-63-570-8520, 82-2-958-6940, FAX: 82-63-570-8999, 82-2-958-6937
Su-Cheol Han e-mail: vethansc@kitox.re.kr,
C. Justin Lee e-mail: cjl@kist.re.kr
Many researchers are using viruses to deliver genes of interest into the brains of laboratory animals. However, certain target brain cells are not easily infected by viruses. Moreover, the differential tropism of different viruses in monkey brain is not well established. We investigated the cellular tropism of lentivirus and adeno-associated virus (AAV) toward neuron and glia in the brain of cynomolgus monkeys (
Keywords: virus tropism, lentivirus, AAV, monkey, neuron, astrocyte