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Article

Original Article

Exp Neurobiol 2016; 25(4): 185-190

Published online August 31, 2016

https://doi.org/10.5607/en.2016.25.4.185

© The Korean Society for Brain and Neural Sciences

Regional Cerebral Glucose Metabolism in Novelty Seeking and Antisocial Personality: A Positron Emission Tomography Study

So Hyeon Park1,2#, Hyun Soo Park1,2,3# and Sang Eun Kim1,2,3*

1Department of Transdisciplinary Studies, Graduate School of Convergence Science and Technology, Seoul National University, Seoul 16229, 2Department of Nuclear Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam 13620, 3Advanced Institutes of Convergence Technology, Suwon 16229, Korea

Correspondence to: *To whom correspondence should be addressed.
TEL: 82-31-787-7671, FAX: 82-31-787-4018
e-mail: kse@snu.ac.kr
#So Hyeon Park and Hyun Soo Park contributed equally to the present study in the experimental design, manuscript writing, and discussion.

Received: March 24, 2016; Revised: July 8, 2016; Accepted: July 8, 2016

Abstract

Novelty seeking (NS) and antisocial personality (ASP) are commonly exhibited by those who suffer from addictions, such as substance abuse. NS has been suggested to be a fundamental aspect of ASP. To investigate the neurobiological substrate of NS and ASP, we tested the relationship between regional cerebral glucose metabolism and the level of NS, determining the differences between individuals with and without ASP. Seventy-two healthy adults (43 males, mean age±SD=38.8±16.6 years, range=20~70 years; 29 females, 44.2±20.1 years, range=19~72 years) underwent resting-state brain positron emission tomography (PET) 40 minutes after 18F-fluorodeoxyglucose (FDG) injection. Within 10 days of the FDG PET study, participants completed Cloninger's 240-item Temperament and Character Inventory (TCI) to determine NS scores. Participants with and without ASP were grouped according to their TCI profiles. Statistical parametric mapping analysis was performed using the FDG PET and TCI profile data. NS scores positively correlated with metabolism in the left anterior cingulate gyrus and the insula on both sides of the brain and negatively correlated with metabolism in the right pallidum and putamen. Participants with ASP showed differences in cerebral glucose metabolism across various cortical and subcortical regions, mainly in the frontal and prefrontal areas. These data demonstrate altered regional cerebral glucose metabolism in individuals with NS and ASP and inform our understanding of the neurobiological substrates of problematic behaviors and personality disorders.

Keywords: Neural Substrate of Personality, Novelty Seeking, Antisocial Personality, FDG PET, Statistical Parametric Mapping (SPM)