Articles
Article Tools
 View Full Text |
 Abstract |
 Article as PDF |
 Print this Article |
 Pubmed |
 PMC |
 PubReader |
 Export to Citation |
 Email Alerts |
 Open Access |
Share this article on :
Stats or Metrics
Article
Rapid Communication
Exp Neurobiol 2016; 25(6): 342-346
Published online December 31, 2016
https://doi.org/10.5607/en.2016.25.6.342
© The Korean Society for Brain and Neural Sciences
Mildly Increased Mechanical Nociceptive Sensitivity in REV-ERBα Knock-out Mice
Jaehyun Lee1, Hyoung-Gon Ko1, Kyungjin Kim2 and Bong-Kiun Kaang1*
1Department of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul 08826, 2Department of Brain and Cognitive Science, DGIST, Daegu 42988, Korea
Correspondence to: *To whom correspondence should be addressed.
TEL: 82-2-880-7525, FAX: 82-2-884-9577
e-mail: kaang@ snu.ac.kr
Abstract
- Go to
- Abstract
Nociception is one of the most complex senses that is affected not only by external stimulation but also internal conditions. Previous studies have suggested that circadian rhythm is important in modulating nociception. REV-ERBα knock-out (KO) mice have disrupted circadian rhythm and altered mood-related phenotypes. In this study, we examined the role of REV-ERBα in inflammatory nociception. We found that the nociceptive sensitivity of KO mice was partially enhanced in mechanical nociception. However, this partial alteration was independent of the circadian rhythm. Taken together, deletion of REV-ERBα induced a mild change in mechanical nociceptive sensitivity but this alteration was not dependent on the circadian rhythm.
Keywords: Circadian rhythm, REV-ERBα, Nociception, Inflammatory pain
