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Exp Neurobiol 2017; 26(3): 141-150
Published online June 30, 2017
https://doi.org/10.5607/en.2017.26.3.141
© The Korean Society for Brain and Neural Sciences
So Young Park1, So Young Jang1, Yoon Kyoung Shin1, Dong Keun Jung1, Byeol A Yoon3, Jong Kook Kim3, Young Rae Jo1, Hye Jeong Lee2 and Hwan Tae Park1*
Departments of 1Physiology and 2Pharmacology, 3Peripheral Neuropath Research Center (PNRC), College of Medicine, Dong-A University, Busan 49201, Korea
Correspondence to: *To whom correspondence should be addressed.
TEL: 82-51-240-2636, FAX: 82-51-247-3318
e-mail: phwantae@dau.ac.kr
The vertebrate neuromuscular junction (NMJ) is considered as a “tripartite synapse” consisting of a motor axon terminal, a muscle endplate, and terminal Schwann cells that envelope the motor axon terminal. The neuregulin 1 (NRG1)-ErbB2 signaling pathway plays an important role in the development of the NMJ. We previously showed that Grb2-associated binder 1 (Gab1), a scaffolding mediator of receptor tyrosine kinase signaling, is required for NRG1-induced peripheral nerve myelination. Here, we determined the role of Gab1 in the development of the NMJ using muscle-specific conditional Gab1 knockout mice. The mutant mice showed delayed postnatal maturation of the NMJ. Furthermore, the selective loss of the
Keywords: Neuregulin-1, Grb2-associated binders (Gab), Terminal Schwann cells, Neuromuscular junction, Synaptic elimination