Highlights
  • Original Article | August 31, 2021

    This study identifies the intracellular signaling pathways and related genes that may contribute to the pathogenesis of intellectual disability in children with Duchenne muscular dystrophy, thus providing a potential target for the development of future therapeutics.

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    This study identifies the intracellular signaling pathways and related genes that may contribute to the pathogenesis of intellectual disability in children with Duchenne muscular dystrophy, thus providing a potential target for the development of future therapeutics.
    Jahong Koo, Subin Park, Soo-Eun Sung et al.
  • Original Article | August 31, 2021

    During brain development and adulthood, the extracellular matrix compositions of the basal lamina and fractones influence the maintenance and migration of neural stem/progenitor cells (NS/PCs) in the subventricular zone. Using micro-contact printing-based competition assay, we have found that adult NS/PCs preferred to adhere to laminin over collagen type IV. The ECM preference could be manipulated by SDF1 and integrin signaling, which may provide a basis for context-dependent NS/PC positioning.

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    During brain development and adulthood, the extracellular matrix compositions of the basal lamina and fractones influence the maintenance and migration of neural stem/progenitor cells (NS/PCs) in the subventricular zone. Using micro-contact printing-based competition assay, we have found that adult NS/PCs preferred to adhere to laminin over collagen type IV. The ECM preference could be manipulated by SDF1 and integrin signaling, which may provide a basis for context-dependent NS/PC positioning.
    Hyun Jung Kim, Eunsoo Lee, Myungwoo Nam et al.
  • Original Article | August 31, 2021

    The apoE4 isoform-dependent injury response exhibited selectivity in the hippocampus revealing reduced synaptic protein expression and early higher glial and monocyte activation.

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    The apoE4 isoform-dependent injury response exhibited selectivity in the hippocampus revealing reduced synaptic protein expression and early higher glial and monocyte activation.
    Sung Eun Lee, Haijie Yang, Youngjun Sung et al.
  • Original Article | August 31, 2021

    Hyperoxygenation condition increases MMP-9 expression via a MeCP2-dependent mechanism in HT22 hippocampal neuronal cells. Hyperoxygenation treatment in Tg-APP/PS1 mice markedly reduces amyloid-beta accumulation via MeCP2-dependent upregulation of MMP-2 and MMP-9 in the brain.

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    Hyperoxygenation condition increases MMP-9 expression via a MeCP2-dependent mechanism in HT22 hippocampal neuronal cells. Hyperoxygenation treatment in Tg-APP/PS1 mice markedly reduces amyloid-beta accumulation via MeCP2-dependent upregulation of MMP-2 and MMP-9 in the brain.
    Juli Choi, Hyejin Kwon and Pyung-Lim Han
Vol.30 No.4 | August 31, 2021

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Extracellular matrix landscape in the subventricular zone of the adult mouse brain