The cover illustrates a study using Alzheimer’s disease mouse models to detect oral expression of disease-specific biomarkers. It features a confocal image of a mouse circumvallate papilla stained with anti-phosphorylated Tau (left). The expression of phosphorylated Tau (pTau), a key pathogenic protein in Alzheimer’s disease, was discovered in the mouse taste buds. The expression level of pTau was elevated in Alzheimer’s disease model mice, suggesting that the tongue may serve as a potential novel diagnostic target (right scheme).