-
Original Article | August 31, 2021
This study identifies the intracellular signaling pathways and related genes that may contribute to the pathogenesis of intellectual disability in children with Duchenne muscular dystrophy, thus providing a potential target for the development of future therapeutics.
Show more
This study identifies the intracellular signaling pathways and related genes that may contribute to the pathogenesis of intellectual disability in children with Duchenne muscular dystrophy, thus providing a potential target for the development of future therapeutics.Jahong Koo, Subin Park, Soo-Eun Sung et al. -
Original Article | August 31, 2021
During brain development and adulthood, the extracellular matrix compositions of the basal lamina and fractones influence the maintenance and migration of neural stem/progenitor cells (NS/PCs) in the subventricular zone. Using micro-contact printing-based competition assay, we have found that adult NS/PCs preferred to adhere to laminin over collagen type IV. The ECM preference could be manipulated by SDF1 and integrin signaling, which may provide a basis for context-dependent NS/PC positioning.
Show more
During brain development and adulthood, the extracellular matrix compositions of the basal lamina and fractones influence the maintenance and migration of neural stem/progenitor cells (NS/PCs) in the subventricular zone. Using micro-contact printing-based competition assay, we have found that adult NS/PCs preferred to adhere to laminin over collagen type IV. The ECM preference could be manipulated by SDF1 and integrin signaling, which may provide a basis for context-dependent NS/PC positioning.Hyun Jung Kim, Eunsoo Lee, Myungwoo Nam et al. -
Original Article | August 31, 2021
The apoE4 isoform-dependent injury response exhibited selectivity in the hippocampus revealing reduced synaptic protein expression and early higher glial and monocyte activation.
Show more
The apoE4 isoform-dependent injury response exhibited selectivity in the hippocampus revealing reduced synaptic protein expression and early higher glial and monocyte activation.Sung Eun Lee, Haijie Yang, Youngjun Sung et al. -
Original Article | August 31, 2021
Hyperoxygenation condition increases MMP-9 expression via a MeCP2-dependent mechanism in HT22 hippocampal neuronal cells. Hyperoxygenation treatment in Tg-APP/PS1 mice markedly reduces amyloid-beta accumulation via MeCP2-dependent upregulation of MMP-2 and MMP-9 in the brain.
Show more
Hyperoxygenation condition increases MMP-9 expression via a MeCP2-dependent mechanism in HT22 hippocampal neuronal cells. Hyperoxygenation treatment in Tg-APP/PS1 mice markedly reduces amyloid-beta accumulation via MeCP2-dependent upregulation of MMP-2 and MMP-9 in the brain.Juli Choi, Hyejin Kwon and Pyung-Lim Han
PDF.jpg)
VISITORS
since Jan. 01, 2020| TODAY | 149 |
|---|---|
| TOTAL | 169,232 |
News
-
Here is the winner of the 2021 EN Best Article Awards announced at the KSBNS 2021 Virtual Conference held on May 20~21, 2021. Congratulations to Dr. Joungha Won...…
Show more2021-05-28 -
Here are the winners of the 2020 EN Best Article Awards announced at the KSBNS 2020 Virtual Conference held onNovember 16~17, 2020. - Review Article Congratulat...…
Show more2020-11-18 -
기초과학연구원 인지및사회성연구단 이창준 단장과 동(同)소속 한영은 박사가 2020년 한국과학기술단체총연합회(KOFST, 이...…
Show more2020-06-30
