Highlights
  • Review Article | August 31, 2023

    Single and repetitive TBI may initiate various long-term consequences that may be caused by differences in the neuropathological changes, including the TDP-43 proteinopathy.

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    Single and repetitive TBI may initiate various long-term consequences that may be caused by differences in the neuropathological changes, including the TDP-43 proteinopathy.
    Tamara Janković and Kristina Pilipović
  • Review Article | August 31, 2023

    Alzheimer's disease (AD) and cerebral amyloid angiopathy (CAA) have both been linked to the accumulation of Amyloid-β in the brain. The impaired clearance of this protein is a key factor in its accumulation. To prevent the deposition of Amyloid-β, which is central to the pathogenesis of AD and CAA, there is a need for strategies that enhance its clearance both in the brain and the periphery.

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    Alzheimer's disease (AD) and cerebral amyloid angiopathy (CAA) have both been linked to the accumulation of Amyloid-β in the brain. The impaired clearance of this protein is a key factor in its accumulation. To prevent the deposition of Amyloid-β, which is central to the pathogenesis of AD and CAA, there is a need for strategies that enhance its clearance both in the brain and the periphery.
    Rahat Ullah and Eun Jeong Lee
  • Original Article | August 31, 2023

    The present study shows that NAG-1 TG mice have similar basal sensitivity with WT mice against mechanical and thermal stimuli and that female TG mice show delayed peak period of the second phase nociception in formalin-induced pain, but spinal neuronal activation and nociceptive behaviors induced by subcutaneous formalin are not suppressed by NAG-1 overexpression.

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    The present study shows that NAG-1 TG mice have similar basal sensitivity with WT mice against mechanical and thermal stimuli and that female TG mice show delayed peak period of the second phase nociception in formalin-induced pain, but spinal neuronal activation and nociceptive behaviors induced by subcutaneous formalin are not suppressed by NAG-1 overexpression.
    Sheu-Ran Choi, Jaehak Lee, Ji-Young Moon et al.
  • Original Article | August 31, 2023

    Presenilin 2 N141I mutation dampens the amplitude of circadian rhythm in immune cell-specific manner without central clock modulation or animal behavior rhythm.

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    Presenilin 2 N141I mutation dampens the amplitude of circadian rhythm in immune cell-specific manner without central clock modulation or animal behavior rhythm.
    Hyeri Nam, Boil Kim, Younghwan Lee et al.
  • Original Article | August 31, 2023

    Error in decision-making based on sensory cue is not attributed to misrepresentation of sensory information but to biases that exist even before the presentation of stimulus.

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    Error in decision-making based on sensory cue is not attributed to misrepresentation of sensory information but to biases that exist even before the presentation of stimulus.
    Soyoung Chae, Duho Sihn and Sung-Phil Kim
  • Original Article | August 31, 2023

    Calcium transients in anterior cingulate cortex (ACC) neurons diminish consistently during sleep deprivation, albeit this process is reversible. The administration of gallic acid (GA) notably mitigated the decline of calcium transients in ACC neurons. GA was also shown to alleviate oxidative stress in the brain and improve cognitive impairment caused by sleep deprivation.

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    Calcium transients in anterior cingulate cortex (ACC) neurons diminish consistently during sleep deprivation, albeit this process is reversible. The administration of gallic acid (GA) notably mitigated the decline of calcium transients in ACC neurons. GA was also shown to alleviate oxidative stress in the brain and improve cognitive impairment caused by sleep deprivation.
    Xiaogang Pang, Yifan Xu, Shuoxin Xie et al.
Vol.32 No.4 | August 31, 2023

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We report the machine learning-assisted image analysis tool for assessing intracortical axonal plasticity after focal ischemic stroke. Axonal plasticity of the brain is considered to be an underlying mechanism of spontaneous recovery following a stroke. Therefore, precise analysis of intracortical axonal plasticity after a stroke is crucial. Our study developed a machine learning algorithm-based analysis tool to reveal axonal projections after a stroke. Application of this tool revealed substantial axonal sprouting from RFA to the premotor cortex after a focal stroke.