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Review Article | June 30, 2020
Based on the mode of inheritance, gene therapy for inherited peripheral neuropathy (IPN) can be categorized into three types. For recessively inherited cases, gene replacement can be applied to compensate for the lack of functional protein. For dominantly inherited IPN, a disease modifying gene can be applied, along with silencing the mutant allele. For a copy number variation type of IPN, gene silencing and gene editing-based transcriptional modulation can be applied.
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Based on the mode of inheritance, gene therapy for inherited peripheral neuropathy (IPN) can be categorized into three types. For recessively inherited cases, gene replacement can be applied to compensate for the lack of functional protein. For dominantly inherited IPN, a disease modifying gene can be applied, along with silencing the mutant allele. For a copy number variation type of IPN, gene silencing and gene editing-based transcriptional modulation can be applied.Rajarathinam Thenmozhi, Ji-Su Lee, Na Young Park et al. -
Original Article | June 30, 2020
By negatively regulating NeuroD1, Erk maintains the progenitor pools at mid-stage brain develop-ment and promotes glial cell differentiation of progenitor cells at late-stage brain development.
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By negatively regulating NeuroD1, Erk maintains the progenitor pools at mid-stage brain develop-ment and promotes glial cell differentiation of progenitor cells at late-stage brain development.Tae-young Lee, In-Su Cho, Narayan Bashyal et al. -
Original Article | June 30, 2020
Deciphering complex neural circuit connectivity is essential for understanding how cognitive functions are regulated in the brain. However, currently available tracing tools are not suitable for dissecting multiple synaptic connectivity. This study presents a novel anterograde viral tracing system called “cFork” that allows differential labeling of postsynaptic neurons based on two different presynaptic inputs by adopting anterograde AAV1 and dual gene expression vectors.
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Deciphering complex neural circuit connectivity is essential for understanding how cognitive functions are regulated in the brain. However, currently available tracing tools are not suitable for dissecting multiple synaptic connectivity. This study presents a novel anterograde viral tracing system called “cFork” that allows differential labeling of postsynaptic neurons based on two different presynaptic inputs by adopting anterograde AAV1 and dual gene expression vectors.Jun-Young Oh, Jeong-Ho Han, Hyoeun Lee et al. -
Original Article | June 30, 2020
Deficiency of glia maturation factor enhances neurotrophic factors, improves behavioral impairments and reduces neuroinflammation after traumatic brain injury in mice.
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Deficiency of glia maturation factor enhances neurotrophic factors, improves behavioral impairments and reduces neuroinflammation after traumatic brain injury in mice.Govindhasamy Pushpavathi Selvakumar, Mohammad Ejaz Ahmed, Shankar S. Iyer et al.
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기초과학연구원 인지및사회성연구단 이창준 단장과 동(同)소속 한영은 박사가 2020년 한국과학기술단체총연합회(KOFST, 이...…
Show more2020-06-30 -
Korean researchers have developed new technology that can detect COVID-19 virus infections within 4 hours at a laboratory. The team led by Lee Chang-joon,...…
Show more2020-03-12 -
This event combined introductory presentations by the editors from major scientific journals and an open panel discussion. The aim was to have an open exchan...…
Show more2019-12-02
