- Dysregulated cholesterol metabolism causes a wide spectrum of neuropsychiatric disorders.
- Proper cholesterol metabolism or balance is essential for maintaining the normal structure and function of the neurons.
- Balancing cholesterol metabolism may be a novel way to resolve neurological symptoms in patients with neuropsychiatric disorders
Highlights
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Review Article | April 30, 2023
- Dysregulated cholesterol metabolism causes a wide spectrum of neuropsychiatric disorders.
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- Proper cholesterol metabolism or balance is essential for maintaining the normal structure and function of the neurons.
- Balancing cholesterol metabolism may be a novel way to resolve neurological symptoms in patients with neuropsychiatric disorders
So Yeong Cheon -
Original Article | April 30, 2023
This study indicates that subdiaphragmatic vagotomy (SDV) suppresses nocifensive behaviors via reduction of the neuronal activity of glutamatergic neurons in the anterior insular cortex under formalin-induced acute inflammatory pain condition. Therefore, these results suggest that the aIC provide a new alternative for therapeutic target to modulate inflammatory pain.
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This study indicates that subdiaphragmatic vagotomy (SDV) suppresses nocifensive behaviors via reduction of the neuronal activity of glutamatergic neurons in the anterior insular cortex under formalin-induced acute inflammatory pain condition. Therefore, these results suggest that the aIC provide a new alternative for therapeutic target to modulate inflammatory pain.Yea Jin Kim, Grace J Lee, Sang Wook Shim et al. -
Short Communication | April 30, 2023
The cerebellar Purkinje cells have a strict interspike interval threshold for dendritic Ca2++ transients, to block unnecessary Ca2++ transients induced by its spontaneous activity.
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The cerebellar Purkinje cells have a strict interspike interval threshold for dendritic Ca2++ transients, to block unnecessary Ca2++ transients induced by its spontaneous activity.Dong Cheol Jang, Changhyeon Ryu, Geehoon Chung et al. -
Original Article | April 30, 2023
Recognition memory is impaired in wild-type mice following acute stress but not in
Show moreFkbp5 -knockout mice. Compared to wild-type mice,Fkbp5 -knockout mice exhibited lower plasma corticosterone levels and less hippocampal cytosolic glucocorticoid receptor phosphorylation following acute stress.
Recognition memory is impaired in wild-type mice following acute stress but not inFkbp5 -knockout mice. Compared to wild-type mice,Fkbp5 -knockout mice exhibited lower plasma corticosterone levels and less hippocampal cytosolic glucocorticoid receptor phosphorylation following acute stress.Yong-Jae Jeon, Bo-Ryoung Choi, Min-Sun Park et al. -
Short Communication | April 30, 2023
While the structure of biological neural networks is the basis of neural computation, it is seldom referred to in the design of artificial neural networks (ANNs). As an expansion of a recent study, we use the connectomes, the entire neural networks of adult male and hermaphrodite
Show moreCaenorhabditis elegans to explore the computational power of the connectome-based ANN architectures. We extracted a directed acyclic graph from the connectome to construct the neural network architecture and trained it to classify the images of handwritten digits and fashion-related items and show that more realistic network architecture yields higher accuracy in comparison to the previous study. This study suggests that biological networks have an architecture for general neural computation, and the inspiration of neuroscience is still crucial to the advancement of artificial intelligence.
While the structure of biological neural networks is the basis of neural computation, it is seldom referred to in the design of artificial neural networks (ANNs). As an expansion of a recent study, we use the connectomes, the entire neural networks of adult male and hermaphroditeCaenorhabditis elegans to explore the computational power of the connectome-based ANN architectures. We extracted a directed acyclic graph from the connectome to construct the neural network architecture and trained it to classify the images of handwritten digits and fashion-related items and show that more realistic network architecture yields higher accuracy in comparison to the previous study. This study suggests that biological networks have an architecture for general neural computation, and the inspiration of neuroscience is still crucial to the advancement of artificial intelligence.Changjoo Park and Jinseop S. Kim -
Original Article | April 30, 2023
Higher functional connectivity in the somatosensory subnetworks implicating exaggerated pain perception and lower functional connectivity in the prefronto-parieto-cingulo-thalamic subnetworks indicating impaired cognitive-affective pain processing may underlie pain catastrophizing in complex regional pain syndrome, a chronic neuropathic pain disorder.
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Higher functional connectivity in the somatosensory subnetworks implicating exaggerated pain perception and lower functional connectivity in the prefronto-parieto-cingulo-thalamic subnetworks indicating impaired cognitive-affective pain processing may underlie pain catastrophizing in complex regional pain syndrome, a chronic neuropathic pain disorder.Haejin Hong, Chaewon Suh, Eun Namgung et al.
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Highly Cited Papers
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Special Topic | April 30, 2020
In response to the desperate need for a low-cost, easy-access, laboratory-ready, laboratory-safe protocol for an ultra-sensitive detection of SARS-CoV2, which has caused a world-wide outbreak of Coronavirus Disease 2019, we have established a real-time reverse-transcription polymerase chain reaction (rtPCR)-based assay protocol composed of easy specimen collection from a subject via pharyngeal swab, Trizol-based RNA purification, and SYBRGreen-based rtPCR. This protocol shows an accuracy and sensitivity limit of 1~10 virus particles as we tested with a known Lentivirus. The cost for each sample is estimated to be less than 15 US Dollars with overall time it takes for an entire protocol of less than 4 hours.
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In response to the desperate need for a low-cost, easy-access, laboratory-ready, laboratory-safe protocol for an ultra-sensitive detection of SARS-CoV2, which has caused a world-wide outbreak of Coronavirus Disease 2019, we have established a real-time reverse-transcription polymerase chain reaction (rtPCR)-based assay protocol composed of easy specimen collection from a subject via pharyngeal swab, Trizol-based RNA purification, and SYBRGreen-based rtPCR. This protocol shows an accuracy and sensitivity limit of 1~10 virus particles as we tested with a known Lentivirus. The cost for each sample is estimated to be less than 15 US Dollars with overall time it takes for an entire protocol of less than 4 hours.Joungha Won, Solji Lee, Myungsun Park et al. -
Review Article | December 31, 2014David Snead and David Eliezer
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Review Article | April 30, 2018
Astrocytes and microglia support well-being and well-function of the brain through diverse activities. Parkinson’s disease (PD)-related genes are expressed in these cells. Therefore, mutations of PD genes may alter the functions of these cells, and contribute to disease onset and progression
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Astrocytes and microglia support well-being and well-function of the brain through diverse activities. Parkinson’s disease (PD)-related genes are expressed in these cells. Therefore, mutations of PD genes may alter the functions of these cells, and contribute to disease onset and progressionEun-Hye Joe, Dong-Joo Choi, Jiawei An et al.
News
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Here is the winner of the 2021 EN Best Article Awards announced at the KSBNS 2021 Virtual Conference held on May 20~21, 2021. Congratulations to Dr. Joungha Won...…
Show more2021-05-28 -
Here are the winners of the 2020 EN Best Article Awards announced at the KSBNS 2020 Virtual Conference held onNovember 16~17, 2020. - Review Article Congratulat...…
Show more2020-11-18 -
기초과학연구원 인지및사회성연구단 이창준 단장과 동(同)소속 한영은 박사가 2020년 한국과학기술단체총연합회(KOFST, 이...…
Show more2020-06-30
