Highlights
  • Short Communication | October 31, 2022

    Non-mammalian chicken Best1, Ca2+-activated anion channel, has a significant permeability for glutamate.

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    Non-mammalian chicken Best1, Ca2+-activated anion channel, has a significant permeability for glutamate.
    Jung Moo Lee, Changdev Gorakshnath Gadhe, Hyunji Kang et al.
  • Original Article | October 31, 2022

    Neuroglobin may play a role in reducing blood-brain barrier leakage due to its association with platelet-derived growth factor receptor β-positive pericytes in the ischemic brain.

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    Neuroglobin may play a role in reducing blood-brain barrier leakage due to its association with platelet-derived growth factor receptor β-positive pericytes in the ischemic brain.
    Yeojin Kim, Mingee Kim, So-Dam Kim et al.
  • Original Article | October 31, 2022

    Sustained peritoneal LPS infusion induced autophagy in the dentate gyrus of the hippocampus, including both granule neurons and nonneural cells. The induced autophagy was responsible for the suppression of mTOR/s6k signaling. The autophagy milieu might facilitate the asymmetrical self-renewal of SOX2-positive cells to astrocytes. 3MA: 3-methyladenine; LPS: lipopolysaccharide; mTOR: mammalian target of rapamycin; NSC: neural stem cells; SOX2: SRY-Box transcription Factor 2.

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    Sustained peritoneal LPS infusion induced autophagy in the dentate gyrus of the hippocampus, including both granule neurons and nonneural cells. The induced autophagy was responsible for the suppression of mTOR/s6k signaling. The autophagy milieu might facilitate the asymmetrical self-renewal of SOX2-positive cells to astrocytes. 3MA: 3-methyladenine; LPS: lipopolysaccharide; mTOR: mammalian target of rapamycin; NSC: neural stem cells; SOX2: SRY-Box transcription Factor 2.
    Wen-Chung Liu, Chih-Wei Wu, Mu-Hui Fu et al.
  • Short Communication | October 31, 2022

    The primary somatosensory cortex uses a multiplexed coding strategy to differentiate between itch and pain, and represents the reciprocal inhibition between the two.

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    The primary somatosensory cortex uses a multiplexed coding strategy to differentiate between itch and pain, and represents the reciprocal inhibition between the two.
    Seunghui Woo, Yoo Rim Kim, Myeong Seong Bak et al.
  • Original Article | October 31, 2022

    The existence of visuosocial memory in mice remains elusive. Here, we developed a novel visuosocial memory test using either a portrait picture of a conspecific or a mirrored self-image. CA2 neuron-specific deletion of PLCγ1 showed impaired visuosocial preference memory, but not avoidance memory.

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    The existence of visuosocial memory in mice remains elusive. Here, we developed a novel visuosocial memory test using either a portrait picture of a conspecific or a mirrored self-image. CA2 neuron-specific deletion of PLCγ1 showed impaired visuosocial preference memory, but not avoidance memory.
    Sunpil Kim, Jeongyeon Kim, Yongmin Mason Park et al.
  • Short Communication | October 31, 2022

    Alexithymia is characterized by impairments in the processing of emotions. In the present study, we investigated WM tracts to discover potential associations between alexithymia and WM integrity to identify the neural basis of impaired emotional self-awareness in MDD. We identified significantly lower FA values in that left inferior longitudinal fasciculus in patients with MDD and it also showed negative associations with alexithymia.

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    Alexithymia is characterized by impairments in the processing of emotions. In the present study, we investigated WM tracts to discover potential associations between alexithymia and WM integrity to identify the neural basis of impaired emotional self-awareness in MDD. We identified significantly lower FA values in that left inferior longitudinal fasciculus in patients with MDD and it also showed negative associations with alexithymia.
    Youbin Kang, Aram Kim, Wooyoung Kang et al.
Vol.31 No.5 | October 31, 2022

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Glutamate permeation and conduction through the ion-conducting pathway of chicken Best1

Representative molecular dynamics simulation system with umbrella sampling simulation for exerting external pulling force to permeate glutamate through chicken Best1 (cBest1). cBest1, green structure; glutamate, sphere model; DPPC lipids, cyan model; water, transparent red and white sphere.