Highlights
  • Original Article | June 30, 2021

    The Gli1 promoter is active in the external granule cell layer (EGL) and Bergman glia (BGs) in the developing cerebellum. Administration of tamoxifen during early postnatal days (P4-7) induces expression of Cre recombinase driven by Gli1 promoter in EGL and BGs whereas during late postnatal days (P19-22) tamoxifen induces Cre recombinase expression in only BGs. This system is suggested for conditional knockout of genes of interest from cerebellar granule cell neurons (GCNs) and/or BGs.

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    The Gli1 promoter is active in the external granule cell layer (EGL) and Bergman glia (BGs) in the developing cerebellum. Administration of tamoxifen during early postnatal days (P4-7) induces expression of Cre recombinase driven by Gli1 promoter in EGL and BGs whereas during late postnatal days (P19-22) tamoxifen induces Cre recombinase expression in only BGs. This system is suggested for conditional knockout of genes of interest from cerebellar granule cell neurons (GCNs) and/or BGs.
    Jung-Mi Choi, Rakshya Acharya, Subash Marasini et al.
  • Short Communication | June 30, 2021

    An et al. demonstrate that the differential proximity of astrocytic Best1 at the inhibitory and excitatory synapse in APP/PS1 and MAOB KO mice by using Lattice SIM super-resolution microscopy.

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    An et al. demonstrate that the differential proximity of astrocytic Best1 at the inhibitory and excitatory synapse in APP/PS1 and MAOB KO mice by using Lattice SIM super-resolution microscopy.
    Heeyoung An, Wuhyun Koh, SeungHee Kang et al.
  • Original Article | June 30, 2021

    An et al. demonstrate that adenovirus injection into SNpc causes severe reactive astrogliosis and exacerbates the A53T-α-synuclein-mediated PD pathology.

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    An et al. demonstrate that adenovirus injection into SNpc causes severe reactive astrogliosis and exacerbates the A53T-α-synuclein-mediated PD pathology.
    Heeyoung An, Hyowon Lee, Seulkee Yang et al.
  • Original Article | June 30, 2021

    Ciliogenesis is not directly regulated by LRRK2 kinase activity. Comparison of ciliogenesis in various G2019S /WT pairs with different genetic backgrounds exhibits different patterns, suggesting its genetic specificity.

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    Ciliogenesis is not directly regulated by LRRK2 kinase activity. Comparison of ciliogenesis in various G2019S /WT pairs with different genetic backgrounds exhibits different patterns, suggesting its genetic specificity.
    Hyejung Kim, Hyuna Sim, Joo-Eun Lee et al.
Vol.30 No.3 | June 30, 2021

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A SIM image exhibiting vGLUT2 and Best1 with GFAP in an astrocyte in CA1 stratum radiatum region of APP/PS1 mouse.