Highlights
  • Review Article | June 30, 2020

    Based on the mode of inheritance, gene therapy for inherited peripheral neuropathy (IPN) can be categorized into three types. For recessively inherited cases, gene replacement can be applied to compensate for the lack of functional protein. For dominantly inherited IPN, a disease modifying gene can be applied, along with silencing the mutant allele. For a copy number variation type of IPN, gene silencing and gene editing-based transcriptional modulation can be applied.

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    Based on the mode of inheritance, gene therapy for inherited peripheral neuropathy (IPN) can be categorized into three types. For recessively inherited cases, gene replacement can be applied to compensate for the lack of functional protein. For dominantly inherited IPN, a disease modifying gene can be applied, along with silencing the mutant allele. For a copy number variation type of IPN, gene silencing and gene editing-based transcriptional modulation can be applied.
    Rajarathinam Thenmozhi, Ji-Su Lee, Na Young Park et al.
  • Original Article | June 30, 2020

    By negatively regulating NeuroD1, Erk maintains the progenitor pools at mid-stage brain develop-ment and promotes glial cell differentiation of progenitor cells at late-stage brain development.

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    By negatively regulating NeuroD1, Erk maintains the progenitor pools at mid-stage brain develop-ment and promotes glial cell differentiation of progenitor cells at late-stage brain development.
    Tae-young Lee, In-Su Cho, Narayan Bashyal et al.
  • Original Article | June 30, 2020

    Deciphering complex neural circuit connectivity is essential for understanding how cognitive functions are regulated in the brain. However, currently available tracing tools are not suitable for dissecting multiple synaptic connectivity. This study presents a novel anterograde viral tracing system called “cFork” that allows differential labeling of postsynaptic neurons based on two different presynaptic inputs by adopting anterograde AAV1 and dual gene expression vectors.

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    Deciphering complex neural circuit connectivity is essential for understanding how cognitive functions are regulated in the brain. However, currently available tracing tools are not suitable for dissecting multiple synaptic connectivity. This study presents a novel anterograde viral tracing system called “cFork” that allows differential labeling of postsynaptic neurons based on two different presynaptic inputs by adopting anterograde AAV1 and dual gene expression vectors.
    Jun-Young Oh, Jeong-Ho Han, Hyoeun Lee et al.
  • Original Article | June 30, 2020

    Deficiency of glia maturation factor enhances neurotrophic factors, improves behavioral impairments and reduces neuroinflammation after traumatic brain injury in mice.

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    Deficiency of glia maturation factor enhances neurotrophic factors, improves behavioral impairments and reduces neuroinflammation after traumatic brain injury in mice.
    Govindhasamy Pushpavathi Selvakumar, Mohammad Ejaz Ahmed, Shankar S. Iyer et al.
Vol.29 No.3 | June 30, 2020

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Visualizing Dual Presynaptic Inputs using cFork System

Visualizing Dual Presynaptic Inputs using cFork System

This scheme presents a viral tracing technique called cFork (‘see-Fork'), which is suitable for dual presynaptic input-defined labeling of postsynaptic neurons. This technique includes anterograde transport of AAV1 with Cre or FlpO from presynaptic neurons to the postsynaptic neuron with AAV5 containing a dual gene expression cassette.