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Original Article | August 31, 2021
This study identifies the intracellular signaling pathways and related genes that may contribute to the pathogenesis of intellectual disability in children with Duchenne muscular dystrophy, thus providing a potential target for the development of future therapeutics.
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This study identifies the intracellular signaling pathways and related genes that may contribute to the pathogenesis of intellectual disability in children with Duchenne muscular dystrophy, thus providing a potential target for the development of future therapeutics.Jahong Koo, Subin Park, Soo-Eun Sung et al. -
Original Article | August 31, 2021
During brain development and adulthood, the extracellular matrix compositions of the basal lamina and fractones influence the maintenance and migration of neural stem/progenitor cells (NS/PCs) in the subventricular zone. Using micro-contact printing-based competition assay, we have found that adult NS/PCs preferred to adhere to laminin over collagen type IV. The ECM preference could be manipulated by SDF1 and integrin signaling, which may provide a basis for context-dependent NS/PC positioning.
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During brain development and adulthood, the extracellular matrix compositions of the basal lamina and fractones influence the maintenance and migration of neural stem/progenitor cells (NS/PCs) in the subventricular zone. Using micro-contact printing-based competition assay, we have found that adult NS/PCs preferred to adhere to laminin over collagen type IV. The ECM preference could be manipulated by SDF1 and integrin signaling, which may provide a basis for context-dependent NS/PC positioning.Hyun Jung Kim, Eunsoo Lee, Myungwoo Nam et al. -
Original Article | August 31, 2021
The apoE4 isoform-dependent injury response exhibited selectivity in the hippocampus revealing reduced synaptic protein expression and early higher glial and monocyte activation.
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The apoE4 isoform-dependent injury response exhibited selectivity in the hippocampus revealing reduced synaptic protein expression and early higher glial and monocyte activation.Sung Eun Lee, Haijie Yang, Youngjun Sung et al. -
Original Article | August 31, 2021
Hyperoxygenation condition increases MMP-9 expression via a MeCP2-dependent mechanism in HT22 hippocampal neuronal cells. Hyperoxygenation treatment in Tg-APP/PS1 mice markedly reduces amyloid-beta accumulation via MeCP2-dependent upregulation of MMP-2 and MMP-9 in the brain.
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Hyperoxygenation condition increases MMP-9 expression via a MeCP2-dependent mechanism in HT22 hippocampal neuronal cells. Hyperoxygenation treatment in Tg-APP/PS1 mice markedly reduces amyloid-beta accumulation via MeCP2-dependent upregulation of MMP-2 and MMP-9 in the brain.Juli Choi, Hyejin Kwon and Pyung-Lim Han
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Here is the winner of the 2021 EN Best Article Awards announced at the KSBNS 2021 Virtual Conference held on May 20~21, 2021. Congratulations to Dr. Joungha Won...…
Show more2021-05-28 -
Here are the winners of the 2020 EN Best Article Awards announced at the KSBNS 2020 Virtual Conference held onNovember 16~17, 2020. - Review Article Congratulat...…
Show more2020-11-18 -
기초과학연구원 인지및사회성연구단 이창준 단장과 동(同)소속 한영은 박사가 2020년 한국과학기술단체총연합회(KOFST, 이...…
Show more2020-06-30
