Highlights
  • Review Article | April 30, 2023

    - Dysregulated cholesterol metabolism causes a wide spectrum of neuropsychiatric disorders.
    - Proper cholesterol metabolism or balance is essential for maintaining the normal structure and function of the neurons.
    - Balancing cholesterol metabolism may be a novel way to resolve neurological symptoms in patients with neuropsychiatric disorders

    Show more full text
    - Dysregulated cholesterol metabolism causes a wide spectrum of neuropsychiatric disorders.
    - Proper cholesterol metabolism or balance is essential for maintaining the normal structure and function of the neurons.
    - Balancing cholesterol metabolism may be a novel way to resolve neurological symptoms in patients with neuropsychiatric disorders
    So Yeong Cheon
  • Original Article | April 30, 2023

    This study indicates that subdiaphragmatic vagotomy (SDV) suppresses nocifensive behaviors via reduction of the neuronal activity of glutamatergic neurons in the anterior insular cortex under formalin-induced acute inflammatory pain condition. Therefore, these results suggest that the aIC provide a new alternative for therapeutic target to modulate inflammatory pain.

    Show more full text
    This study indicates that subdiaphragmatic vagotomy (SDV) suppresses nocifensive behaviors via reduction of the neuronal activity of glutamatergic neurons in the anterior insular cortex under formalin-induced acute inflammatory pain condition. Therefore, these results suggest that the aIC provide a new alternative for therapeutic target to modulate inflammatory pain.
    Yea Jin Kim, Grace J Lee, Sang Wook Shim et al.
  • Short Communication | April 30, 2023

    The cerebellar Purkinje cells have a strict interspike interval threshold for dendritic Ca2++ transients, to block unnecessary Ca2++ transients induced by its spontaneous activity.

    Show more full text
    The cerebellar Purkinje cells have a strict interspike interval threshold for dendritic Ca2++ transients, to block unnecessary Ca2++ transients induced by its spontaneous activity.
    Dong Cheol Jang, Changhyeon Ryu, Geehoon Chung et al.
  • Original Article | April 30, 2023

    Recognition memory is impaired in wild-type mice following acute stress but not in Fkbp5-knockout mice. Compared to wild-type mice, Fkbp5-knockout mice exhibited lower plasma corticosterone levels and less hippocampal cytosolic glucocorticoid receptor phosphorylation following acute stress.

    Show more full text
    Recognition memory is impaired in wild-type mice following acute stress but not in Fkbp5-knockout mice. Compared to wild-type mice, Fkbp5-knockout mice exhibited lower plasma corticosterone levels and less hippocampal cytosolic glucocorticoid receptor phosphorylation following acute stress.
    Yong-Jae Jeon, Bo-Ryoung Choi, Min-Sun Park et al.
  • Short Communication | April 30, 2023

    While the structure of biological neural networks is the basis of neural computation, it is seldom referred to in the design of artificial neural networks (ANNs). As an expansion of a recent study, we use the connectomes, the entire neural networks of adult male and hermaphrodite Caenorhabditis elegans to explore the computational power of the connectome-based ANN architectures. We extracted a directed acyclic graph from the connectome to construct the neural network architecture and trained it to classify the images of handwritten digits and fashion-related items and show that more realistic network architecture yields higher accuracy in comparison to the previous study. This study suggests that biological networks have an architecture for general neural computation, and the inspiration of neuroscience is still crucial to the advancement of artificial intelligence.

    Show more full text
    While the structure of biological neural networks is the basis of neural computation, it is seldom referred to in the design of artificial neural networks (ANNs). As an expansion of a recent study, we use the connectomes, the entire neural networks of adult male and hermaphrodite Caenorhabditis elegans to explore the computational power of the connectome-based ANN architectures. We extracted a directed acyclic graph from the connectome to construct the neural network architecture and trained it to classify the images of handwritten digits and fashion-related items and show that more realistic network architecture yields higher accuracy in comparison to the previous study. This study suggests that biological networks have an architecture for general neural computation, and the inspiration of neuroscience is still crucial to the advancement of artificial intelligence.
    Changjoo Park and Jinseop S. Kim
  • Original Article | April 30, 2023

    Higher functional connectivity in the somatosensory subnetworks implicating exaggerated pain perception and lower functional connectivity in the prefronto-parieto-cingulo-thalamic subnetworks indicating impaired cognitive-affective pain processing may underlie pain catastrophizing in complex regional pain syndrome, a chronic neuropathic pain disorder.

    Show more full text
    Higher functional connectivity in the somatosensory subnetworks implicating exaggerated pain perception and lower functional connectivity in the prefronto-parieto-cingulo-thalamic subnetworks indicating impaired cognitive-affective pain processing may underlie pain catastrophizing in complex regional pain syndrome, a chronic neuropathic pain disorder.
    Haejin Hong, Chaewon Suh, Eun Namgung et al.
Vol.32 No.2 | April 30, 2023

VISITORS

since Jan. 01, 2020
TODAY 386
TOTAL 375,677
Search
the Korean Society for Brain and Neural Sciences en Experimental Neurobiology in SCIe As of August 2017 Covered from 2015
2017 Impact Factor 3.810. 2018 Impact Factor 2.360. 2019 Impact Factor 2.370. 2020 Impact Factor 3.261. 2021 Impact Factor 3.800. Bexco, busan, korea

Forthcoming

  • In Preparation

Highly Cited Papers

  • Special Topic | April 30, 2020

    In response to the desperate need for a low-cost, easy-access, laboratory-ready, laboratory-safe protocol for an ultra-sensitive detection of SARS-CoV2, which has caused a world-wide outbreak of Coronavirus Disease 2019, we have established a real-time reverse-transcription polymerase chain reaction (rtPCR)-based assay protocol composed of easy specimen collection from a subject via pharyngeal swab, Trizol-based RNA purification, and SYBRGreen-based rtPCR. This protocol shows an accuracy and sensitivity limit of 1~10 virus particles as we tested with a known Lentivirus. The cost for each sample is estimated to be less than 15 US Dollars with overall time it takes for an entire protocol of less than 4 hours.

    Show more full text
    In response to the desperate need for a low-cost, easy-access, laboratory-ready, laboratory-safe protocol for an ultra-sensitive detection of SARS-CoV2, which has caused a world-wide outbreak of Coronavirus Disease 2019, we have established a real-time reverse-transcription polymerase chain reaction (rtPCR)-based assay protocol composed of easy specimen collection from a subject via pharyngeal swab, Trizol-based RNA purification, and SYBRGreen-based rtPCR. This protocol shows an accuracy and sensitivity limit of 1~10 virus particles as we tested with a known Lentivirus. The cost for each sample is estimated to be less than 15 US Dollars with overall time it takes for an entire protocol of less than 4 hours.
    Joungha Won, Solji Lee, Myungsun Park et al.
  • Review Article | December 31, 2014
    David Snead and David Eliezer
  • Review Article | April 30, 2018

    Astrocytes and microglia support well-being and well-function of the brain through diverse activities. Parkinson’s disease (PD)-related genes are expressed in these cells. Therefore, mutations of PD genes may alter the functions of these cells, and contribute to disease onset and progression

    Show more full text
    Astrocytes and microglia support well-being and well-function of the brain through diverse activities. Parkinson’s disease (PD)-related genes are expressed in these cells. Therefore, mutations of PD genes may alter the functions of these cells, and contribute to disease onset and progression
    Eun-Hye Joe, Dong-Joo Choi, Jiawei An et al.

News

close
We report that cerebellar Purkinje cells have an ISIT for induction of Ca2+ transients in distal dendrites, that is, the ISI should be under 3 ms. In a normal, tonic firing mode, the PC fires at constant frequencies of 50~100 Hz and the SS firings cannot reach the ISIT. Therefore, dendritic Ca2+ transients would not be introduced in normally firing PCs. Our results suggest that ISIT might play an important role as a shutter, opening and closing the information window and enabling the induction and maintenance of synaptic plasticity between parallel fiber and PC in an activity-dependent manner.