Highlights
  • Review Article | February 28, 2023

    We analyzed the revision process of the Brain Research Promotion Act using Kingdon’s Multiple Streams Framework and developed a new strategy to implement neuroethics in Korea.

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    We analyzed the revision process of the Brain Research Promotion Act using Kingdon’s Multiple Streams Framework and developed a new strategy to implement neuroethics in Korea.
    Tae-Woo Kang, Tai-Won Oh and Sung-Jin Jeong
  • Review Article | February 28, 2023

    In this study, we share the practical and technical difficulties we have experienced in pursuing a government-funded project to facilitate the integration of neuroscience and neuroethics and to introduce a new three-dimensional operational framework, along with a detailed step-by-step workflow to apply this framework. This framework will enable a meaningful integration of the two fields to promote responsible innovation in neuroscience and neurotechnology.

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    In this study, we share the practical and technical difficulties we have experienced in pursuing a government-funded project to facilitate the integration of neuroscience and neuroethics and to introduce a new three-dimensional operational framework, along with a detailed step-by-step workflow to apply this framework. This framework will enable a meaningful integration of the two fields to promote responsible innovation in neuroscience and neurotechnology.
    Anita S. Jwa, Jiwon Shim, Sinu Choi et al.
  • Original Article | February 28, 2023

    Neuronal activity in the entorhinal cortex of the rats were modulated during the stimulus-free trace interval following trace fear conditioning. Specifically, an increased number of units decreased their firing rates during the trace interval.

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    Neuronal activity in the entorhinal cortex of the rats were modulated during the stimulus-free trace interval following trace fear conditioning. Specifically, an increased number of units decreased their firing rates during the trace interval.
    Mi-Seon Kong, Namsoo Kim, Kyeong Im Jo et al.
  • Original Article | February 28, 2023

    Using wireless brain stimulation conditioning, this study found that hungry mice showed a high degree of violation of social rule and hasty social decisions-making during rule-observance behavior tests.

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    Using wireless brain stimulation conditioning, this study found that hungry mice showed a high degree of violation of social rule and hasty social decisions-making during rule-observance behavior tests.
    Abdelrahman M. Alkahwaji, Hee-Sup Shin and C. Justin Lee
  • Original Article | February 28, 2023

    The present study demonstrated that Reelin acts cooperatively with APP to regulate dendritic spine formation through Ras-ERK-CREB signaling.

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    The present study demonstrated that Reelin acts cooperatively with APP to regulate dendritic spine formation through Ras-ERK-CREB signaling.
    Hyun-ju Lee, Jin-Hee Park, Justin H. Trotter et al.
Vol.32 No.1 | February 28, 2023

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The cover art shows that Reelin promotes dendritic spine formation via Ras/ERK/CREB signaling-dependent manner. In addition, our results demonstrated that Reelin did not increase dendritic spine number when APP expression was reduced in primary hippocampal neurons or in APP knockout mice, indicating that Reelin acts cooperatively with APP to modulate dendritic spine formation. Thus, Our data are the first to demonstrate that normal APP function is critical for Reelin-mediated dendritic spinogenesis at synapses.