Highlights
  • Original Article | December 31, 2021

    Chronic restraint stress (CRS) leads to increased food intake and decreased activity of POMC neurons, without affecting NPY neurons, in the arcuate nucleus of the hypothalamus. CRS induces the decreased excitatory inputs onto POMC neurons and increased their threshold to generate action potential resulting in the overall decrease in the activity of anorexigenic POMC neurons, which would disturb the balance between the orexigenic signal from NPY neurons and the anorexigenic signal from POMC neurons.

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    Chronic restraint stress (CRS) leads to increased food intake and decreased activity of POMC neurons, without affecting NPY neurons, in the arcuate nucleus of the hypothalamus. CRS induces the decreased excitatory inputs onto POMC neurons and increased their threshold to generate action potential resulting in the overall decrease in the activity of anorexigenic POMC neurons, which would disturb the balance between the orexigenic signal from NPY neurons and the anorexigenic signal from POMC neurons.
    Go Eun Ha and Eunji Cheong
  • Original Article | December 31, 2021

    Long-term injection of thyroxine can induce insomnia in rats.
    The mechanism behind these physiological disorders is the sympathetic nervous system.

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    Long-term injection of thyroxine can induce insomnia in rats.
    The mechanism behind these physiological disorders is the sympathetic nervous system.
    Zhifu Ai, Hongwei He, Tingting Wang et al.
  • Original Article | December 31, 2021

    Briefly, OA inhibits neuronal pyroptosis by reducing miR-186-5p expression and upregulating target protein Ngb levels, playing a neuroprotective role in cerebral ischaemia.

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    Briefly, OA inhibits neuronal pyroptosis by reducing miR-186-5p expression and upregulating target protein Ngb levels, playing a neuroprotective role in cerebral ischaemia.
    Shi-Chang Cai, Xiu-Ping Li, Xing Li et al.
  • Original Article | December 31, 2021

    Hyperoxygenation is a non-pharmacological method that can be used to treat tissue damages involving vascular problems including acute and chronic brain diseases. This strategy needs to overcome certain safety and effectiveness concerns and it deserves to expand its utilities. The present study considers optimization options of hyperoxygenation treatment to stably rescue maladaptive changes in a stress-induced model of depression.

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    Hyperoxygenation is a non-pharmacological method that can be used to treat tissue damages involving vascular problems including acute and chronic brain diseases. This strategy needs to overcome certain safety and effectiveness concerns and it deserves to expand its utilities. The present study considers optimization options of hyperoxygenation treatment to stably rescue maladaptive changes in a stress-induced model of depression.
    Juli Choi, Hye-Jin Kwon, Ju-Young Seoh and Pyung-Lim Han
  • Original Article | December 31, 2021

    The Alzheimer’s disease mouse model has long-term episodic memory deficits related to altered sharp-wave ripple-coupled oscillations within the hippocampus and retrosplenial cortex.

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    The Alzheimer’s disease mouse model has long-term episodic memory deficits related to altered sharp-wave ripple-coupled oscillations within the hippocampus and retrosplenial cortex.
    Hyunwoo Yang and Yong Jeong
  • Original Article | December 31, 2021

    We explored regional differences of brain structures through various aspects of cortical thickness, degree of gyrification, and sulcal depth, then studied their impact on functional connectivity and clinical relevance. Our results suggest the association between altered cortical thickness of post central gyrus (PoCG) and abnormal functional networks in male ADPs. These findings can be useful to understanding the neural mechanisms of anatomical, functional and clinical features of individuals with alcoholism.

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    We explored regional differences of brain structures through various aspects of cortical thickness, degree of gyrification, and sulcal depth, then studied their impact on functional connectivity and clinical relevance. Our results suggest the association between altered cortical thickness of post central gyrus (PoCG) and abnormal functional networks in male ADPs. These findings can be useful to understanding the neural mechanisms of anatomical, functional and clinical features of individuals with alcoholism.
    Shin-Eui Park, Yeong-Jae Jeon and Hyeon-Man Baek
Vol.30 No.6 | December 31, 2021

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Cortical thickness patterns in healthy controls (HCs) and alcohol-dependence patients (ADPs).

We explored regional differences of brain structures through various aspects of cortical thickness, degree of gyrification, and sulcal depth, then studied their impact on functional connectivity and clinical relevance. Our results suggest the association between altered cortical thickness of post central gyrus (PoCG) and abnormal functional networks in male ADPs. These findings can be useful to understanding the neural mechanisms of anatomical, functional and clinical features of individuals with alcoholism.