Highlights
  • Perspective | December 31, 2024

    Astrocytes have been known to support neuronal function, but until now, memory storage and recall has thought to be largely controlled by neurons. In this article, we shed light on recent research published by Williamson et al that, for the first time, shows astrocytes to participate in memory formation and recall.

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    Astrocytes have been known to support neuronal function, but until now, memory storage and recall has thought to be largely controlled by neurons. In this article, we shed light on recent research published by Williamson et al that, for the first time, shows astrocytes to participate in memory formation and recall.
    Mridula Bhalla and C. Justin Lee
  • Original Article | December 31, 2024

    In the injured Schwann cells, fascaplysin (Fas) interacts with androgen receptor (AR) as a novel on-target as well as CDK4/CCND1 complex as an original on-target, and the nuclear translocation of Fas/AR complex is suppressed during peripheral nerve degeneration. The multi-targeted action regulates to proliferate negatively and differentiate positive Schwann cells

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    In the injured Schwann cells, fascaplysin (Fas) interacts with androgen receptor (AR) as a novel on-target as well as CDK4/CCND1 complex as an original on-target, and the nuclear translocation of Fas/AR complex is suppressed during peripheral nerve degeneration. The multi-targeted action regulates to proliferate negatively and differentiate positive Schwann cells
    Hyung-Joo Chung, Ja-Eun Kim, Youngbuhm Huh et al.
  • Original Article | December 31, 2024

    We establish differences in resting state connectivity of cerebellar-cortical networks focusing on early aging by contrasting a late middle-age group with a young adult group.

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    We establish differences in resting state connectivity of cerebellar-cortical networks focusing on early aging by contrasting a late middle-age group with a young adult group.
    Dilara Derya and Christian Wallraven
  • Original Article | December 31, 2024

    The SNUH-dementia brain bank provides high-quality brain tissues and cellular models for neurodegenerative diseases research, operating under strict protocols. Their findings reveal varying clinical-pathological concordance rates across conditions, with many cases of AD, LBD, and FTLD had mixed pathologies. This prevalence of mixed diseases emphasizes the need for improved diagnostic criteria and more accurate biomarkers and highlights the crucial role of brain banks in advancing diagnostic accuracy and neurodegenerative disease research.

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    The SNUH-dementia brain bank provides high-quality brain tissues and cellular models for neurodegenerative diseases research, operating under strict protocols. Their findings reveal varying clinical-pathological concordance rates across conditions, with many cases of AD, LBD, and FTLD had mixed pathologies. This prevalence of mixed diseases emphasizes the need for improved diagnostic criteria and more accurate biomarkers and highlights the crucial role of brain banks in advancing diagnostic accuracy and neurodegenerative disease research.
    Kwanghoon Lee, Seong-Ik Kim, Yu-Mi Shim et al.
Vol.33 No.6 | December 31, 2024

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KSBNS-APSN 2024 en Experimental Neurobiology in SCIe As of August 2017 Covered from 2015
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The Seoul National University Hospital Dementia Brain Bank (SNUH-DBB) collected 162 specimens from 2015 to 2024, with a median donor age of 73 years and a 9.5-hour median postmortem interval. APOE genotype distribution and common neuropathological diagnoses were recorded. Varying concordance rates between pathological and clinical diagnoses highlighted the need for improved diagnostic criteria. SNUH-DBB provides high-quality brain tissues and cell models, supporting translational research in dementia and neurodegenerative diseases.