The importance of genetic contributions to the epilepsies is now well established. Mutations in over 70 genes now define biological pathways leading to the epilepsy. These mutations disrupt a very large spectrum of biologic function. Some of the inherited errors alter the intrinisic ion channel properties directly responsible for neuronal hyperexcitability and others have impact on the brain development or cellular regulation. This paper reviews the pathogenic implications of the established genetic mutations and briefly mentioned the susceptible genes in hereditary or familial epilepsy syndrome.

Keywords: Genetic, epilepsy