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Article
Original Article
Exp Neurobiol 2022; 31(6): 361-375
Published online December 31, 2022
https://doi.org/10.5607/en22028
© The Korean Society for Brain and Neural Sciences
Dopamine Receptor Supports the Potentiation of Intrinsic Excitability and Synaptic LTD in Temporoammonic-CA1 Synapse
Hye-Hyun Kim1,2‡, Suk-Ho Lee1,2, Won-Kyung Ho1,2* and Kisang Eom3*
1Department of Physiology, Seoul National University College of Medicine, Seoul 03080, 2Neuroscience Research Center, Seoul National University College of Medicine, Seoul 03080, 3Department of Physiology, School of Medicine, Keimyung University, Daegu 42601, Korea
Correspondence to: *To whom correspondence should be addressed.
Kisang Eom, TEL: 82-53-258-7416, FAX: 82-53-258-7412
e-mail: hitiet21@gmail.com
Won-Kyung Ho, TEL: 82-2-740-8226, FAX: 82-2-763-9667
e-mail: wonkyung@snu.ac.kr
‡Hye-Hyun Kim's Present address: Department of Physiology, Michigan State University, East Lansing, MI 48824, USA
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Dopaminergic projection to the hippocampus from the ventral tegmental area or locus ceruleus has been considered to play an essential role in the acquisition of novel information. Hence, the dopaminergic modulation of synaptic plasticity in the hippocampus has been widely studied. We examined how the D1 and D2 receptors influenced the mGluR5-mediated synaptic plasticity of the temporoammonic-CA1 synapses and showed that the dopaminergic modulation of the temporoammonic-CA1 synapses was expressed in various ways. Our findings suggest that the dopaminergic system in the hippocampal CA1 region regulates the long-term synaptic plasticity and processing of the novel information.
Graphical Abstract
Keywords: Dopamine, Temporoammonic pathway, CA1, LTD
