Exp Neurobiol 2023; 32(1): 42-55

Published online February 28, 2023

https://doi.org/10.5607/en22044

© The Korean Society for Brain and Neural Sciences

Reelin and APP Cooperatively Modulate Dendritic Spine Formation In Vitro and In Vivo

Hyun-ju Lee^1*, Jin-Hee Park^1,2, Justin H. Trotter³, James N. Maher⁴, Kathleen E. Keenoy⁴, You Mi Jang¹, Youngeun Lee⁵, Jae-Ick Kim⁵, Edwin J. Weeber³ and Hyang-Sook Hoe^1,2,4*

¹Department of Neural Development and Disease, Korea Brain Research Institute (KBRI), Daegu 41062, ²Department of Brain and Cognitive Sciences, Daegu Gyeongbuk Institute of Science & Technology (DGIST), Daegu 42988, Korea, ³Department of Molecular Pharmacology and Physiology, USF Health Byrd Alzheimer’s Institute, University of South Florida, Tampa, FL 33613, ⁴Department of Neuroscience, Georgetown University Medical Center, Washington, DC 20057, USA, ⁵Department of Biological Sciences, Ulsan National Institute of Science and Technology (UNIST), Ulsan 44919, Korea

Correspondence to: ^*To whom correspondence should be addressed.
Hyang-Sook Hoe, TEL: 82-53-980-8310, FAX: 82-53-980-8309
e-mail: sookhoe72@kbri.re.kr
Hyun-ju Lee, TEL: 82-53-980-8313, FAX: 82-53-980-8309
e-mail: hjlee@kbri.re.kr

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Keywords: APP, Reelin, Dendritic spine, Alzheimer’s disease, Ras signaling