Exp Neurobiol 2020; 29(6): 417-424
Published online December 7, 2020
© The Korean Society for Brain and Neural Sciences
Hwan-Ki Kim1, Dong-won Lee1, Eunmi Kim1, Inyoung Jeong1, Suhyun Kim1*, Bum-Joon Kim2* and Hae-Chul Park1*
1Department of Biomedical Sciences, College of Medicine, Korea University,
2Department of Neurosurgery, Korea University Ansan Hospital, Ansan 15355, Korea
Correspondence to: *To whom correspondence should be addressed.
Hae-Chul Park, TEL: 82-31-412-6713, FAX: 82-31-412-6729
Bum-Joon Kim, TEL: 82-31-412-5050, FAX: 82-31-412-5054
Suhyun Kim, TEL: 82-31-412-6725, FAX: 82-31-412-6729
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
The myelination of axons in the vertebrate nervous system through oligodendrocytes promotes efficient axonal conduction, which is required for the normal function of neurons. The central nervous system (CNS) can regenerate damaged myelin sheaths through the process of remyelination, but the failure of remyelination causes neurological disorders such as multiple sclerosis. In mammals, parenchymal oligodendrocyte progenitor cells (OPCs) are known to be the principal cell type responsible for remyelination in demyelinating diseases and traumatic injuries to the adult CNS. However, growing evidence suggests that neural stem cells (NSCs) are implicated in remyelination in animal models of demyelination. We have previously shown that