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Article
Original Article
Exp Neurobiol 2022; 31(5): 332-342
Published online October 31, 2022
https://doi.org/10.5607/en22033
© The Korean Society for Brain and Neural Sciences
Visuosocial Preference Memory, but Not Avoidance Memory, Requires PLCγ1 in the CA2 Hippocampus
Sunpil Kim1,2, Jeongyeon Kim3, Yongmin Mason Park2,4, Pann-Ghill Suh5 and C. Justin Lee1,2,4*
1KU-KIST Graduate School of Converging Science and Technology, Korea University, Seoul 02841, 2Center for Cognition and Sociality, Institute for Basic Science (IBS), Daejeon 34126, 3Emotion, Cognition and Behavior Research Group, Korea Brain Research Institute (KBRI), Daegu 41062, 4IBS School, University of Science and Technology (UST), Daejeon 34113, 5Korea Brain Research Institute (KBRI), Daegu 41062, Korea
Correspondence to: *To whom correspondence should be addressed.
TEL: 82-42-878-9150, FAX: 82-42-878-9151
e-mail: cjl@ibs.re.kr
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Visuosocial memory is defined as stored visual information containing social context. Primates have a powerful ability to associate visuosocial memory with episodic memory. However, the existence of visuosocial memory in mice remains unclear. Here, we design a novel vision-specific social memory test using a portrait picture or mirrored self-image and demonstrate that mice can distinguish conspecific from other species by forming a visuosocial memory. Because CA2 hippocampus has been reported as a critical brain region for social memory, we develop CA2-specific blockade of memory formation through deletion of phospholipase C gamma 1 (PLCγ1), which is a key molecule in the brain-derived neurotrophic factor (BDNF) signaling pathway. Interestingly, these mice have intact sociability but impaired social memory in three chamber test and five-trial social memory test, which is highly dependent on visual information. Finally, PLCγ1 deletion in CA2 impairs visuosocial preference memory, but not avoidance memory, whereas non-social object recognition is intact. Our study proposes that mice have visuosocial memory, just as primates and humans.
Graphical Abstract
Keywords: Visuosocial memory, CA2 hippocampus, Phospholipase C gamma 1, Social behavior
